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G6pd2 Gene Detail
Summary
  • Symbol
    G6pd2
  • Name
    glucose-6-phosphate dehydrogenase 2
  • Synonyms
    G6pdx-ps1, Gpd-2, Gpd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105977
    NCBI Gene: 14380
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:61966186-61967820 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 31.99 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105977
 protein coding gene Chr5:61966159-61968506 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029559
 protein coding gene Chr5:61321696-61324043 (+)
A/J MGP_AJ_G0029527
 protein coding gene Chr5:58979475-58981815 (+)
AKR/J MGP_AKRJ_G0029475
 protein coding gene Chr5:60852911-60855251 (+)
BALB/cJ MGP_BALBcJ_G0029536
 protein coding gene Chr5:59658763-59661111 (+)
C3H/HeJ MGP_C3HHeJ_G0029259
 protein coding gene Chr5:61193897-61196245 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029990
 protein coding gene Chr5:63890846-63893193 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027230
 protein coding gene Chr5:55263183-55265545 (+)
CAST/EiJ MGP_CASTEiJ_G0028667
 protein coding gene Chr5:60292691-60295039 (+)
CBA/J MGP_CBAJ_G0029228
 protein coding gene Chr5:65871774-65874114 (+)
DBA/2J MGP_DBA2J_G0029374
 protein coding gene Chr5:59052529-59054877 (+)
FVB/NJ MGP_FVBNJ_G0029334
 protein coding gene Chr5:58258303-58260643 (+)
LP/J MGP_LPJ_G0029459
 protein coding gene Chr5:61774985-61777332 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029362
 protein coding gene Chr5:68579727-68582067 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030023
 protein coding gene Chr5:60594934-60597281 (+)
PWK/PhJ MGP_PWKPhJ_G0028391
 protein coding gene Chr5:58074370-58076831 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028225
 protein coding gene Chr5:59950928-59953290 (+)
WSB/EiJ MGP_WSBEiJ_G0028748
 protein coding gene Chr5:60752844-60755192 (+)



Homology
more
  • Human Ortholog
    G6PD, glucose-6-phosphate dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    G6PD, glucose-6-phosphate dehydrogenase
  • Synonyms
    CNSHA1, G6PD1
  • Links
    NCBI Gene ID: 2539
    neXtProt AC: NX_P11413
    UniProt: P11413

  • Chr Location
    Xq28; chrX:154517825-154547572 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human G6PD associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    111
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14380 NCBI Gene Model | MGI Sequence Detail 1635 C57BL/6J ±  kb
    transcript NM_019468 RefSeq | MGI Sequence Detail 1635 Not Specified  
    polypeptide P97324 UniProt | EBI | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
      1.1.1.49
    • InterPro Domains
      IPR001282 Glucose-6-phosphate dehydrogenase
      IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal
      IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      P97324 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 4
      cDNA 9
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10222, MGD-MRK-10224, MGD-MRK-33657, MGI:893585
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory