Cox7a2l MGI Mouse Gene Detail - MGI:106015 - cytochrome c oxidase subunit 7A2 like

Symbol

Cox7a2l
Name

cytochrome c oxidase subunit 7A2 like
Synonyms

COX7AR, COX7RP, EB1, Scaf1, SIG-81, SIG81

Feature Type

protein coding gene
IDs

MGI:106015
NCBI Gene: 20463
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:83809346-83821762 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 53.02 cM
Mapping Data

1 experiment

SNPs within 2kb

494 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106015	protein coding gene	Chr17:83809346-83824759 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024073	protein coding gene	Chr17:86582476-86594829 (-)
A/J	MGP_AJ_G0024032	protein coding gene	Chr17:83856202-83868604 (-)
AKR/J	MGP_AKRJ_G0024001	protein coding gene	Chr17:85216645-85230214 (-)
BALB/cJ	MGP_BALBcJ_G0024033	protein coding gene	Chr17:83720910-83733850 (-)
C3H/HeJ	MGP_C3HHeJ_G0023798	protein coding gene	Chr17:86062447-86075801 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024478	protein coding gene	Chr17:89693252-89706122 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021917	protein coding gene	Chr17:79075419-79087544 (-)
CAST/EiJ	MGP_CASTEiJ_G0023277	protein coding gene	Chr17:86782317-86795311 (-)
CBA/J	MGP_CBAJ_G0023772	protein coding gene	Chr17:93378308-93392549 (-)
DBA/2J	MGP_DBA2J_G0023900	protein coding gene	Chr17:82330277-82342565 (-)
FVB/NJ	MGP_FVBNJ_G0023866	protein coding gene	Chr17:81833308-81845516 (-)
LP/J	MGP_LPJ_G0023984	protein coding gene	Chr17:87329739-87344760 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023894	protein coding gene	Chr17:93512864-93526281 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024523	protein coding gene	Chr17:85698546-85710948 (-)
PWK/PhJ	MGP_PWKPhJ_G0023022	protein coding gene	Chr17:81895843-81908496 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022833	protein coding gene	Chr17:82485505-82499582 (-)
WSB/EiJ	MGP_WSBEiJ_G0023344	protein coding gene	Chr17:86551329-86563529 (-)

Human Ortholog

COX7A2L, cytochrome c oxidase subunit 7A2 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX7A2L, cytochrome c oxidase subunit 7A2 like
Synonyms

COX7AR, COX7RP, EB1, SCAF1, SCAFI, SIG81
Links

HGNC:2289

NCBI Gene ID: 9167

neXtProt AC: NX_O14548

UniProt: O14548
Chr Location

2p21; chr2:42333546-42425088 (-) GRCh38

MGI Vertebrate Homology

Cox7a2l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COX7A2L
Protein SuperFamily

COX7A-rel_mt
Gene Tree

Cox7a2l

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Phenotype Summary

16 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
56 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

3
Gene trapped

9
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased running capacity, decrease in metabolic rate and mitochondrial oxidative capacity, whitened brown adipose tissue and severe cold sensitivity. Mice homozygous for an allele encoding the short isoform exhibit higher succinate or pyruvate and malate-driven respiration rates

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All GO Annotations

9
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

98
cDNA Data

201
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cox7a2l

ZFIN cox7a2l

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All Sequences

64
RefSeq

4
UniProt

5
CCDS

CCDS28995.1, CCDS50194.1

Ensembl

ENSMUSG00000024248 (Evidence)
NCBI Gene

20463

			Length	Strain/Species	Flank
genomic	20463	NCBI Gene Model \| MGI Sequence Detail	12417	C57BL/6J	± kb
transcript	NM_001159529	RefSeq \| MGI Sequence Detail	1169	C57BL/6
polypeptide	Q99KD6	UniProt \| EBI \| MGI Sequence Detail	113	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005788 cytochrome c oxidase subunit 7A-related protein, mitochondrial

(term hierarchy)
PDB

7O37, 7O3C, 7O3E, 8PW5
InterPro Domains

IPR039297 Cytochrome c oxidase subunit VII

IPR003177 Cytochrome c oxidase subunit VIIa, metazoa

IPR017267 Cytochrome c oxidase subunit VIIa-related, mitochondrial

IPR036539 Cytochrome c oxidase, subunit VIIa superfamily

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All nucleic 201

cDNA 201

Microarray probesets 6

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MGD-MRK-33697

Summaries

All 88

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 56
Earliest

J:22945 Mixter PF, et al., Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995 Mar 1;154(5):2063-74
Latest

J:359481 Dautan D, et al., Cortico-cortical transfer of socially derived information gates emotion recognition. Nat Neurosci. 2024 Jul;27(7):1318-1332

TSS for Cox7a2l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149599	Chr17:83822028-83822048 (-)	-276 bp
Tssr149598	Chr17:83821740-83821764 (-)	10 bp
Tssr149597	Chr17:83821719-83821734 (-)	35 bp
Tssr149596	Chr17:83810242-83810248 (-)	11,517 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24