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Tra2b Gene Detail
Summary
  • Symbol
    Tra2b
  • Name
    transformer 2 beta
  • Synonyms
    5730405G21Rik, Sfrs10, Silg41, TRA2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:106016
    NCBI Gene: 20462
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22063302-22084755 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.18 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106016
 protein coding gene Chr16:22063299-22084755 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022668
 protein coding gene Chr16:19727593-19750600 (-)
A/J MGP_AJ_G0022629
 protein coding gene Chr16:18771418-18796671 (-)
AKR/J MGP_AKRJ_G0022604
 protein coding gene Chr16:19556028-19580599 (-)
BALB/cJ MGP_BALBcJ_G0022634
 protein coding gene Chr16:18969911-18997235 (-)
C3H/HeJ MGP_C3HHeJ_G0022398
 protein coding gene Chr16:19675098-19698078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023084
 protein coding gene Chr16:20156164-20180528 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020602
 protein coding gene Chr16:19476369-19494955 (-)
CAST/EiJ MGP_CASTEiJ_G0021928
 protein coding gene Chr16:19657307-19677607 (-)
CBA/J MGP_CBAJ_G0022370
 protein coding gene Chr16:21000386-21026618 (-)
DBA/2J MGP_DBA2J_G0022502
 protein coding gene Chr16:18752174-18774427 (-)
FVB/NJ MGP_FVBNJ_G0022478
 protein coding gene Chr16:18724626-18744913 (-)
LP/J MGP_LPJ_G0022570
 protein coding gene Chr16:19476624-19498248 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022497
 protein coding gene Chr16:20559181-20582053 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023095
 protein coding gene Chr16:19513506-19536359 (-)
PWK/PhJ MGP_PWKPhJ_G0021668
 protein coding gene Chr16:18991064-19014038 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0021971
 protein coding gene Chr16:19472103-19494139 (-)



Homology
more
  • Human Ortholog
    TRA2B, transformer 2 beta homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRA2B, transformer 2 beta homolog
  • Synonyms
    Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B
  • Links
    NCBI Gene ID: 6434
    neXtProt AC: NX_P62995
    UniProt: P62995

  • Chr Location
    3q27.2; chr3:185914558-185938103 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced embryo size and early embryonic lethality associated with deficient vasculogenesis and abnormal allantois morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    63
  • cDNA Data
    23
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20462 NCBI Gene Model | MGI Sequence Detail 21454 C57BL/6J ±  kb
    transcript NM_001330555 RefSeq | MGI Sequence Detail 3692 ZRU/MplStud  
    polypeptide P62996 UniProt | EBI | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33698, MGI:2444319
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:22945 Mixter PF, et al., Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995 Mar 1;154(5):2063-74
    • Latest
      J:348634 Lin L, et al., Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. Neuron. 2024 Apr 22;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory