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Gucy2d Gene Detail
Summary
  • Symbol
    Gucy2d
  • Name
    guanylate cyclase 2d
  • Synonyms
    guanylyl cyclase D
  • Feature Type
    protein coding gene
  • IDs
    MGI:106030
    NCBI Gene: 14918
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:98089623-98126685 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1296 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106030
 protein coding gene Chr7:98089623-98126686 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032539
 protein coding gene Chr7:101168432-101207884 (+)
A/J MGP_AJ_G0032513
 protein coding gene Chr7:98673787-98711348 (+)
AKR/J MGP_AKRJ_G0032449
 protein coding gene Chr7:101019502-101056229 (+)
BALB/cJ MGP_BALBcJ_G0032524
 protein coding gene Chr7:98361742-98399269 (+)
C3H/HeJ MGP_C3HHeJ_G0032239
 protein coding gene Chr7:101370697-101411898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033022
 protein coding gene Chr7:105089806-105126825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030017
 protein coding gene Chr7:101109909-101147454 (+)
CAST/EiJ MGP_CASTEiJ_G0031566
 protein coding gene Chr7:92890224-92929660 (+)
CBA/J MGP_CBAJ_G0032206
 protein coding gene Chr7:108674213-108718262 (+)
DBA/2J MGP_DBA2J_G0032358
 protein coding gene Chr7:97005935-97045767 (+)
FVB/NJ MGP_FVBNJ_G0032314
 protein coding gene Chr7:96806387-96844114 (+)
LP/J MGP_LPJ_G0032447
 protein coding gene Chr7:102499567-102538096 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032347
 protein coding gene Chr7:110196574-110233740 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033044
 protein coding gene Chr7:100286506-100323676 (+)
PWK/PhJ MGP_PWKPhJ_G0031284
 protein coding gene Chr7:90086548-90126678 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031127
 protein coding gene Chr7:87564298-87602600 (+)
WSB/EiJ MGP_WSBEiJ_G0031683
 protein coding gene Chr7:100945521-100983407 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozugous for a null allele lack olfactory response to uroguanylin and guanylin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14918 NCBI Gene Model | MGI Sequence Detail 37063 C57BL/6J ±  kb
    transcript NM_001130693 RefSeq | MGI Sequence Detail 3633 ZRU/MplStud  
    polypeptide A0A0U1RPR8 UniProt | EBI | MGI Sequence Detail 1117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
      4.6.1.2
    • InterPro Domains
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR050401 Cyclic nucleotide synthase
      IPR029787 Nucleotide cyclase
      IPR028082 Periplasmic binding protein-like I
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001828 Receptor, ligand binding region
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-33714
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:347977 Serafin EK, et al., Development and characterization of a Gucy2d-cre mouse to selectively manipulate a subset of inhibitory spinal dorsal horn interneurons. PLoS One. 2024;19(3):e0300282
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory