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Lrrn1 Gene Detail
Summary
  • Symbol
    Lrrn1
  • Name
    leucine rich repeat protein 1, neuronal
  • Synonyms
    2810047E21Rik, NLRR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106038
    NCBI Gene: 16979
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:107506729-107547175 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 49.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106038
 protein coding gene Chr6:107506687-107547189 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031097
 protein coding gene Chr6:109784390-109824758 (+)
A/J MGP_AJ_G0031066
 protein coding gene Chr6:105593815-105634529 (+)
AKR/J MGP_AKRJ_G0030997
 protein coding gene Chr6:108447634-108490340 (+)
BALB/cJ MGP_BALBcJ_G0031077
 protein coding gene Chr6:105546774-105587034 (+)
C3H/HeJ MGP_C3HHeJ_G0030631
 protein coding gene Chr6:75848377-75890319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031536
 protein coding gene Chr6:112662320-112702819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028700
 protein coding gene Chr6:102990931-103028598 (+)
CAST/EiJ MGP_CASTEiJ_G0030184
 protein coding gene Chr6:108844365-108886979 (+)
CBA/J MGP_CBAJ_G0030763
 protein coding gene Chr6:117035839-117076172 (+)
DBA/2J MGP_DBA2J_G0030916
 protein coding gene Chr6:104737151-104778150 (+)
FVB/NJ MGP_FVBNJ_G0030870
 protein coding gene Chr6:103802773-103846292 (+)
LP/J MGP_LPJ_G0030996
 protein coding gene Chr6:109834426-109876359 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030904
 protein coding gene Chr6:121234323-121277320 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031563
 protein coding gene Chr6:108440159-108482626 (+)
PWK/PhJ MGP_PWKPhJ_G0029900
 protein coding gene Chr6:103697777-103739243 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029728
 protein coding gene Chr6:107254523-107297498 (+)
WSB/EiJ MGP_WSBEiJ_G0030268
 protein coding gene Chr6:108959588-109000161 (+)



Homology
more
  • Human Ortholog
    LRRN1, leucine rich repeat neuronal 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRN1, leucine rich repeat neuronal 1
  • Synonyms
    FIGLER3, NLRR-1, NLRR1
  • Links
    NCBI Gene ID: 57633
    neXtProt AC: NX_Q6UXK5
    UniProt: Q6UXK5

  • Chr Location
    3p26.2; chr3:3799431-3849834 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 4 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit decreased exploratory activity and females exhibit increased anxiety-like response during open field testing. Mice homozygous other null alleles display abnormal cochlear inner hair cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    974
  • Tissues
    57
  • cDNA Data
    13
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034648 Ensembl Gene Model | MGI Sequence Detail 40447 C57BL/6J ±  kb
    transcript ENSMUST00000049285 Ensembl | MGI Sequence Detail 3700 Not Applicable  
    polypeptide ENSMUSP00000037096 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 3
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33722, MGI:1919960
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 18
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:31287 Taguchi A, et al., Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Brain Res Mol Brain Res. 1996 Jan;35(1-2):31-40
    • Latest
      J:344891 Maunsell HR, et al., Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti. J Neurosci. 2023 Jul 19;43(29):5305-5318
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory