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Dtna Gene Detail
Summary
  • Symbol
    Dtna
  • Name
    dystrobrevin alpha
  • Synonyms
    2210407P21Rik, 87K protein, A0, a-DB-1, adbn, alpha-dystrobrevin, Dtn
  • Feature Type
    protein coding gene
  • IDs
    MGI:106039
    NCBI Gene: 13527
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:23548192-23792772 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 12.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6638 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106039
protein coding gene Chr18:23443063-23792776 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024192
protein coding gene Chr18:21129015-21375999 (+)
A/J MGP_AJ_G0024157
protein coding gene Chr18:20523051-20797808 (+)
AKR/J MGP_AKRJ_G0024126
protein coding gene Chr18:21187489-21434929 (+)
BALB/cJ MGP_BALBcJ_G0024157
protein coding gene Chr18:20600306-20846905 (+)
C3H/HeJ MGP_C3HHeJ_G0023925
protein coding gene Chr18:21096936-21346410 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024599
protein coding gene Chr18:22050554-22301941 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022041
protein coding gene Chr18:20425047-20667722 (+)
CAST/EiJ MGP_CASTEiJ_G0023399
protein coding gene Chr18:20893129-21146377 (+)
CBA/J MGP_CBAJ_G0023893
protein coding gene Chr18:22638237-22899547 (+)
DBA/2J MGP_DBA2J_G0024025
protein coding gene Chr18:20231497-20475517 (+)
FVB/NJ MGP_FVBNJ_G0023991
protein coding gene Chr18:19972552-20220974 (+)
LP/J MGP_LPJ_G0024106
protein coding gene Chr18:21280215-21536374 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024019
protein coding gene Chr18:23658984-23929505 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024647
protein coding gene Chr18:20932582-21181538 (+)
PWK/PhJ MGP_PWKPhJ_G0023143
protein coding gene Chr18:20347189-20599621 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022952
protein coding gene Chr18:21147201-21409689 (+)
WSB/EiJ MGP_WSBEiJ_G0023463
protein coding gene Chr18:20830800-21081344 (+)



Homology
more
  • Human Ortholog
    DTNA, dystrobrevin alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTNA, dystrobrevin alpha
  • Synonyms
    D18S892E, DRP3, DTN, DTN-A, LVNC1, MMCKR2
  • Links
    NCBI Gene ID: 1837
    neXtProt AC: NX_Q9Y4J8
    UniProt: Q9Y4J8

  • Chr Location
    18q12.1; chr18:34493291-34891844 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human DTNA associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants exhibit skeletal and cardiac myopathies and impaired coordination. Neuromuscular junctions appear to form normally, but their postnatal maturation is compromised. Dtna mutations do not increase the severity of Dmd or Utrn mutants whose products are also part of the dystrophin-glycoprotein complex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024302 Ensembl Gene Model | MGI Sequence Detail 244581 C57BL/6J ±  kb
    transcript ENSMUST00000220904 Ensembl | MGI Sequence Detail 3860 Not Applicable  
    polypeptide ENSMUSP00000152288 Ensembl | MGI Sequence Detail 746 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 3
      cDNA 28
      Primer pair 7

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-33723, MGI:1915272
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:28976 Madhavan R, et al., Interactions between dystrophin glycoprotein complex proteins. Biochemistry. 1995 Sep 26;34(38):12204-9
    • Latest
      J:338249 Babu V, et al., RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere's disease. Eur J Neurosci. 2023 Jul 17;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory