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Smc2 Gene Detail
Summary
  • Symbol
    Smc2
  • Name
    structural maintenance of chromosomes 2
  • Synonyms
    5730502P04Rik, CAP-E, Fin16, Smc2l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106067
    NCBI Gene: 14211
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:52439243-52488260 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 28.31 cM, cytoband B3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1435 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106067
 protein coding gene Chr4:52438966-52488365 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028290
 protein coding gene Chr4:51018845-51077623 (+)
A/J MGP_AJ_G0028250
 protein coding gene Chr4:49062386-49115486 (+)
AKR/J MGP_AKRJ_G0028199
 protein coding gene Chr4:50411192-50460165 (+)
BALB/cJ MGP_BALBcJ_G0028269
 protein coding gene Chr4:49243386-49293426 (+)
C3H/HeJ MGP_C3HHeJ_G0027990
 protein coding gene Chr4:50961008-51011735 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028711
 protein coding gene Chr4:52899650-52956300 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026019
 protein coding gene Chr4:46070387-46119413 (+)
CAST/EiJ MGP_CASTEiJ_G0027429
 protein coding gene Chr4:50577386-50633120 (+)
CBA/J MGP_CBAJ_G0027956
 protein coding gene Chr4:54720083-54773574 (+)
DBA/2J MGP_DBA2J_G0028106
 protein coding gene Chr4:49030971-49089598 (+)
FVB/NJ MGP_FVBNJ_G0028073
 protein coding gene Chr4:48278053-48327898 (+)
LP/J MGP_LPJ_G0028205
 protein coding gene Chr4:51116991-51184718 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028097
 protein coding gene Chr4:57929456-57993988 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028746
 protein coding gene Chr4:50647253-50698280 (+)
PWK/PhJ MGP_PWKPhJ_G0027154
 protein coding gene Chr4:48984795-49036036 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026982
 protein coding gene Chr4:49934421-49986007 (+)
WSB/EiJ MGP_WSBEiJ_G0027507
 protein coding gene Chr4:50531996-50583630 (+)



Homology
more
  • Human Ortholog
    SMC2, structural maintenance of chromosomes 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMC2, structural maintenance of chromosomes 2
  • Synonyms
    CAP-E, CAPE, SMC-2, SMC2L1
  • Links
    NCBI Gene ID: 10592
    neXtProt AC: NX_O95347
    UniProt: O95347

  • Chr Location
    9q31.1; chr9:104088263-104141419 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SMC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die embryonically.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1056
  • Tissues
    175
  • cDNA Data
    161
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028312 Ensembl Gene Model | MGI Sequence Detail 49018 C57BL/6J ±  kb
    transcript ENSMUST00000117280 Ensembl | MGI Sequence Detail 5328 Not Applicable  
    polypeptide ENSMUSP00000113940 Ensembl | MGI Sequence Detail 1191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 163
      cDNA 161
      Primer pair 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-33751, MGI:1915197, MGI:2140211, MGI:2140588
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Gene Ontology 13
      Phenotypes 10
    • Earliest
      J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
    • Latest
      J:342169 Xu K, et al., Maternal SMC2 is essential for embryonic development via participating chromosome condensation in mice. J Cell Physiol. 2023 Aug 29;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory