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Gstt2 Gene Detail
Summary
  • Symbol
    Gstt2
  • Name
    glutathione S-transferase, theta 2
  • Synonyms
    mGSTT2, Yrs
  • Feature Type
    protein coding gene
  • IDs
    MGI:106188
    NCBI Gene: 14872
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75667676-75673253 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.58 cM, cytoband B5-C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106188
 protein coding gene Chr10:75666948-75673258 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017367
 protein coding gene Chr10:76023536-76026559 (-)
A/J MGP_AJ_G0017344
 protein coding gene Chr10:73411488-73414524 (-)
AKR/J MGP_AKRJ_G0017305
 protein coding gene Chr10:75380933-75383969 (-)
BALB/cJ MGP_BALBcJ_G0017304
 protein coding gene Chr10:73609318-73612354 (-)
C3H/HeJ MGP_C3HHeJ_G0017128
 protein coding gene Chr10:75429654-75432690 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017762
 protein coding gene Chr10:78715097-78718133 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015452
 protein coding gene Chr10:69865761-69868824 (-)
CAST/EiJ MGP_CASTEiJ_G0016699
 protein coding gene Chr10:75742861-75745899 (-)
CBA/J MGP_CBAJ_G0017100
 protein coding gene Chr10:81784413-81787449 (-)
DBA/2J MGP_DBA2J_G0017205
 protein coding gene Chr10:72712834-72715870 (-)
FVB/NJ MGP_FVBNJ_G0017198
 protein coding gene Chr10:71863209-71866909 (-)
LP/J MGP_LPJ_G0017278
 protein coding gene Chr10:76525414-76528450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017226
 protein coding gene Chr10:83871010-83874729 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017801
 protein coding gene Chr10:75413180-75416216 (-)
PWK/PhJ MGP_PWKPhJ_G0016482
 protein coding gene Chr10:72542719-72545754 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016265
 protein coding gene Chr10:74664115-74667128 (-)
WSB/EiJ MGP_WSBEiJ_G0016762
 protein coding gene Chr10:75401299-75404326 (-)



Homology
more
  • Human Ortholog
    GSTT2, glutathione S-transferase theta 2 (gene/pseudogene)
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTT2, glutathione S-transferase theta 2 (gene/pseudogene)
  • Links
    NCBI Gene ID: 2953
    neXtProt AC: NX_P0CG29
    UniProt: P0CG29

  • Chr Location
    22q11.23; chr22:23980058-23983915 (+)  GRCh38
  • Human Ortholog
    GSTT2B, glutathione S-transferase theta 2B
  • Synonyms
    GSTT2P
  • Links
    NCBI Gene ID: 653689
    neXtProt AC: NX_P0CG30
    UniProt: P0CG30

  • Chr Location
    22q11.23; chr22:23957414-23961206 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Mice homozygous for a disruption in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    139
  • cDNA Data
    12
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14872 NCBI Gene Model | MGI Sequence Detail 5578 C57BL/6J ±  kb
transcript NM_001428510 RefSeq | MGI Sequence Detail 1424 C57BL/6  
polypeptide Q61133 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • EC
    2.5.1.18
  • InterPro Domains
    IPR004046 Glutathione S-transferase, C-terminal
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR004045 Glutathione S-transferase, N-terminal
    IPR051369 Glutathione S-transferase Theta
    IPR040077 Glutathione S-transferase Theta, C-terminal
    IPR040075 Glutathione S-transferase Theta, N-terminal
    IPR040079 Glutathione transferase family
    IPR036249 Thioredoxin-like superfamily
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 12
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33879, MGI:2143556
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory