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Nrp1 Gene Detail
Summary
  • Symbol
    Nrp1
  • Name
    neuropilin 1
  • Synonyms
    Neuropilin-1, NP-1, Npn1, NPN-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106206
    NCBI Gene: 18186
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:129085085-129229844 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 75.78 cM, cytoband E
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2720 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106206
 protein coding gene Chr8:129085085-129231957 (+)
129S1/SvImJ ENSMUSG00200004800
 protein coding gene Chr8:123372200-123520736 (+)
A/J ENSMUSG00195003619
 protein coding gene Chr8:123650466-123798834 (+)
AKR/J ENSMUSG00220001673
 protein coding gene Chr8:123843520-123991973 (+)
BALB/cJ ENSMUSG00180000882
 protein coding gene Chr8:123695174-123843573 (+)
C3H/HeJ ENSMUSG00175005050
 protein coding gene Chr8:123771712-123920088 (+)
C57BL/6NJ ENSMUSG00215000695
 protein coding gene Chr8:123319367-123467849 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031734
 protein coding gene Chr8:119462446-119610187 (+)
CAST/EiJ ENSTCUG00005007275
 protein coding gene Chr8:123093455-123242082 (+)
CBA/J ENSMUSG00210013995
 protein coding gene Chr8:123631053-123779672 (+)
DBA/2J ENSMUSG00185035974
 protein coding gene Chr8:129950026-130098638 (+)
FVB/NJ ENSMUSG00205001210
 protein coding gene Chr8:122618698-122767153 (+)
JF1/MsJ ENSUMUG00000011042
 protein coding gene Chr8:132188557-132337062 (+)
LP/J ENSMUSG00230007262
 protein coding gene Chr8:133554532-133703038 (+)
NOD/ShiLtJ ENSMUSG00190006673
 protein coding gene Chr8:123770257-123917711 (+)
NZO/HlLtJ ENSMUSG00225019914
 protein coding gene Chr8:136882443-137030887 (+)
PWK/PhJ ENSLUMG00010002615
 protein coding gene Chr8:123472938-123621842 (+)
SPRET/EiJ ENSMSPG00010001590
 protein coding gene Chr8:125709573-125856791 (+)
WSB/EiJ ENSIUOG00005002999
 protein coding gene Chr8:124446201-124593605 (+)



Homology
more
  • Human Ortholog
    NRP1, neuropilin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRP1, neuropilin 1
  • Synonyms
    BDCA4, CD304, NP1, NRP, VEGF165R
  • Links
    NCBI Gene ID: 8829
    UniProt: O14786

  • Chr Location
    10p11.22; chr10:33177492-33336262 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nrp1 mouse models; 2 with human NRP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 7 alleles in 12 genetic backgrounds
    11 phenotypes from multigenic genotypes
    173 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show embryonic death, impaired neuronal migration and axon guidance, and vascular defects including a disorganized yolk sac vascular plexus, and malformed brachial arch arteries and great vessels. Mice lacking the cytoplasmic domain show altered retinal arteriovenous patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    224
  • GO References
    46
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1302
  • Tissues
    370
  • cDNA Data
    28
  • Literature Summary
    302
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025810 Ensembl Gene Model | MGI Sequence Detail 144760 C57BL/6J ±  kb
    transcript ENSMUST00000026917 Ensembl | MGI Sequence Detail 3597 Not Applicable  
    polypeptide ENSMUSP00000026917 Ensembl | MGI Sequence Detail 923 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 2
      cDNA 35
      Primer pair 17
      Other 16
      Antibodies 25

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33897
    References
    more
    • Summaries
      All 513
      Developmental Gene Expression 302
      Diseases 1
      Gene Ontology 46
      Phenotypes 173
    • Earliest
      J:30346 Kitsukawa T, et al., Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development. 1995 Dec;121(12):4309-18
    • Latest
      J:388824 Pang KL, et al., Mechanoreceptor plexin D1 regulates lymphatic valve morphogenesis and lymphedema pathogenesis. J Clin Invest. 2026 Jul 1;136(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory