Mnat1 MGI Mouse Gene Detail - MGI:106207

Symbol

Mnat1
Name

menage a trois 1
Synonyms

E130115E11Rik, MAT1

Feature Type

protein coding gene
IDs

MGI:106207
NCBI Gene: 17420
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:73170491-73320762 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 30.37 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

3427 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106207	protein coding gene	Chr12:73158957-73320762 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019834	protein coding gene	Chr12:72998336-73168706 (+)
A/J	MGP_AJ_G0019792	protein coding gene	Chr12:70281024-70439007 (+)
AKR/J	MGP_AKRJ_G0019767	protein coding gene	Chr12:72408808-72567873 (+)
BALB/cJ	MGP_BALBcJ_G0019772	protein coding gene	Chr12:70758898-70912448 (+)
C3H/HeJ	MGP_C3HHeJ_G0019577	protein coding gene	Chr12:72834416-72996937 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020224	protein coding gene	Chr12:75280952-75446449 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017842	protein coding gene	Chr12:67730475-67876191 (+)
CAST/EiJ	MGP_CASTEiJ_G0019129	protein coding gene	Chr12:67627396-67794558 (+)
CBA/J	MGP_CBAJ_G0019547	protein coding gene	Chr12:78139711-78321240 (+)
DBA/2J	MGP_DBA2J_G0019663	protein coding gene	Chr12:70171181-70327653 (+)
FVB/NJ	MGP_FVBNJ_G0019650	protein coding gene	Chr12:69023705-69175715 (+)
LP/J	MGP_LPJ_G0019735	protein coding gene	Chr12:73037381-73193644 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019689	protein coding gene	Chr12:81288387-81457142 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020259	protein coding gene	Chr12:71890166-72053352 (+)
PWK/PhJ	MGP_PWKPhJ_G0018894	protein coding gene	Chr12:64482230-64645923 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018689	protein coding gene	Chr12:66298917-66472008 (+)
WSB/EiJ	MGP_WSBEiJ_G0019180	protein coding gene	Chr12:72481560-72643086 (+)

Human Ortholog

MNAT1, MNAT1 component of CDK activating kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MNAT1, MNAT1 component of CDK activating kinase
Synonyms

CAP35, MAT1, RNF66, TFB3
Links

HGNC:7181

NCBI Gene ID: 4331

neXtProt AC: NX_P51948

UniProt: P51948
Chr Location

14q23.1; chr14:60734742-60969965 (+) GRCh38

MGI Vertebrate Homology

Mnat1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MNAT1
Protein SuperFamily

MAT1_metazoa
Gene Tree

Mnat1

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

20
Targeted

4
Genomic Mutations

1 involving Mnat1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene die as embryos at some point between implantation and gastrulation.

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All GO Annotations

36
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

49
cDNA Data

66
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mnat1

ZFIN mnat1

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All Sequences

45
RefSeq

6
UniProt

4
CCDS

CCDS49087.1

Ensembl

ENSMUSG00000021103 (Evidence)
NCBI Gene

17420

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021103	Ensembl Gene Model \| MGI Sequence Detail	150272	C57BL/6J	± kb
transcript	ENSMUST00000021523	Ensembl \| MGI Sequence Detail	2505	Not Applicable
polypeptide	ENSMUSP00000021523	Ensembl \| MGI Sequence Detail	309	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010496 CDK-activating kinase assembly factor MAT1

(term hierarchy)
InterPro Domains

IPR015877 Cdk-activating kinase assembly factor MAT1, centre

IPR004575 Cdk-activating kinase assembly factor MAT1/Tfb3

IPR003903 Ubiquitin interacting motif

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 74

Genomic 1

cDNA 72

Primer pair 1

Microarray probesets 3

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MGD-MRK-33899, MGI:2445133

Summaries

All 48

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 13
Earliest

J:29185 Fisher RP, et al., Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell. 1995 Oct 6;83(1):47-57
Latest

J:299723 Kafer GR, et al., A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis. Front Cell Dev Biol. 2020;8:416

TSS for Mnat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113781	Chr12:73170468-73170479 (+)	-17 bp
Tssr113782	Chr12:73170483-73170535 (+)	18 bp
Tssr113783	Chr12:73258852-73258857 (+)	88,364 bp
Tssr113784	Chr12:73273689-73273690 (+)	103,199 bp
Tssr113785	Chr12:73308276-73308281 (+)	137,788 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24