Hells MGI Mouse Gene Detail - MGI:106209 - helicase, lymphoid specific

Symbol

Hells
Name

helicase, lymphoid specific
Synonyms

E130115I21Rik, LSH, Lysh, PASG, proliferation-associated SNF2-like, YFK8

Feature Type

protein coding gene
IDs

MGI:106209
NCBI Gene: 15201
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr19:38919359-38959495 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 33.57 cM, cytoband C3-D1
Mapping Data

3 experiments

SNPs within 2kb

807 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106209	protein coding gene	Chr19:38913282-38959495 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025096	protein coding gene	Chr19:38038578-38084354 (+)
A/J	MGP_AJ_G0025072	protein coding gene	Chr19:36183232-36229435 (+)
AKR/J	MGP_AKRJ_G0025040	protein coding gene	Chr19:37384416-37425311 (+)
BALB/cJ	MGP_BALBcJ_G0025070	protein coding gene	Chr19:36280218-36320951 (+)
C3H/HeJ	MGP_C3HHeJ_G0024829	protein coding gene	Chr19:37495209-37540998 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025511	protein coding gene	Chr19:39099538-39143816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022930	protein coding gene	Chr19:35493046-35532834 (+)
CAST/EiJ	MGP_CASTEiJ_G0024296	protein coding gene	Chr19:37360662-37404747 (+)
CBA/J	MGP_CBAJ_G0024806	protein coding gene	Chr19:40968707-41015988 (+)
DBA/2J	MGP_DBA2J_G0024938	protein coding gene	Chr19:36017838-36059634 (+)
FVB/NJ	MGP_FVBNJ_G0024899	protein coding gene	Chr19:35845762-35888973 (+)
LP/J	MGP_LPJ_G0025024	protein coding gene	Chr19:38108210-38148754 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024930	protein coding gene	Chr19:40675867-40732117 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025569	protein coding gene	Chr19:37512892-37552872 (+)
PWK/PhJ	MGP_PWKPhJ_G0024048	protein coding gene	Chr19:35893436-35935409 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023848	protein coding gene	Chr19:36340343-36381274 (+)
WSB/EiJ	MGP_WSBEiJ_G0024363	protein coding gene	Chr19:37595630-37639607 (+)

Human Ortholog

HELLS, helicase, lymphoid specific

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HELLS, helicase, lymphoid specific
Synonyms

ICF4, LSH, Nbla10143, PASG, SALNR, SMARCA6
Links

HGNC:4861

NCBI Gene ID: 3070

neXtProt AC: NX_Q9NRZ9

UniProt: Q9NRZ9
Chr Location

10q23.33; chr10:94545329-94613905 (+) GRCh38

MGI Vertebrate Homology

Hells stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HELLS
Gene Tree

Hells

Diseases

1 with human HELLS associations

				Human Disease	Mouse Models
				immunodeficiency-centromeric instability-facial anomalies syndrome 4 IDs immunodeficiency-centromeric instability-facial anomalies syndrome 4 DOID:0090011 ICD10CM:D84.8 OMIM:616911

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

64 phenotypes from 6 alleles in 6 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

57
Endonuclease-mediated

1
Gene trapped

48
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show DNA hypomethylation, delayed growth, multiorgan and skeletal defects, premature graying, alopecia, low fat deposition, kyphosis, cachexia and early death. Homozygotes for another null allele show neonatal death, low birth weight, lymphoid defects and renal lesions.

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All GO Annotations

34
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

40
cDNA Data

13
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hells

ZFIN hells

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All Sequences

50
RefSeq

6
UniProt

2
CCDS

CCDS29789.1

Ensembl

ENSMUSG00000025001 (Evidence)
NCBI Gene

15201

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025001	Ensembl Gene Model \| MGI Sequence Detail	40137	C57BL/6J	± kb
transcript	ENSMUST00000025965	Ensembl \| MGI Sequence Detail	5868	Not Applicable
polypeptide	ENSMUSP00000025965	Ensembl \| MGI Sequence Detail	821	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029539 lymphoid-specific helicase

(term hierarchy)
EC

3.6.4.-
InterPro Domains

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR044753 HELLS, N-terminal

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR038718 SNF2-like, N-terminal domain superfamily

IPR000330 SNF2, N-terminal

IPR049730 SNF2/RAD5-like, C-terminal helicase domain
GlyGen

Q60848 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

Genomic 5

cDNA 16

Primer pair 1

Other 1

Microarray probesets 5

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MGD-MRK-33900, MGD-MRK-33901, MGI:106208, MGI:1925121, MGI:2147507

Summaries

All 76

Developmental Gene Expression 13

Gene Ontology 13

Phenotypes 32
Earliest

J:32111 Jarvis CD, et al., A novel putative helicase produced in early murine lymphocytes. Gene. 1996 Mar 9;169(2):203-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hells:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156271	Chr19:38919353-38919364 (+)	0 bp
Tssr156272	Chr19:38919372-38919385 (+)	20 bp
Tssr156273	Chr19:38919392-38919412 (+)	43 bp
Tssr156274	Chr19:38919431-38919448 (+)	81 bp
Tssr156275	Chr19:38919452-38919473 (+)	104 bp
Tssr156276	Chr19:38919478-38919483 (+)	122 bp
Tssr156277	Chr19:38919832-38919844 (+)	479 bp
Tssr156278	Chr19:38938699-38938724 (+)	19,353 bp
Tssr156279	Chr19:38942021-38942049 (+)	22,676 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24