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Chrna6 Gene Detail
Summary
  • Symbol
    Chrna6
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 6
  • Synonyms
    Acra6, alpha6 nAChR
  • Feature Type
    protein coding gene
  • IDs
    MGI:106213
    NCBI Gene: 11440
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27893240-27903972 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 16.02 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106213
 protein coding gene Chr8:27893240-27903972 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033509
 protein coding gene Chr8:25618189-25630627 (-)
A/J MGP_AJ_G0033488
 protein coding gene Chr8:24653083-24663736 (-)
AKR/J MGP_AKRJ_G0033413
 protein coding gene Chr8:25485640-25496129 (-)
BALB/cJ MGP_BALBcJ_G0033484
 protein coding gene Chr8:24790444-24801765 (-)
C3H/HeJ MGP_C3HHeJ_G0033198
 protein coding gene Chr8:25682475-25693080 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034001
 protein coding gene Chr8:26646759-26657411 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030951
 protein coding gene Chr8:21855125-21865690 (-)
CAST/EiJ MGP_CASTEiJ_G0032524
 protein coding gene Chr8:25187417-25198125 (-)
CBA/J MGP_CBAJ_G0033174
 protein coding gene Chr8:27676387-27687120 (-)
DBA/2J MGP_DBA2J_G0033328
 protein coding gene Chr8:24652481-24663272 (-)
FVB/NJ MGP_FVBNJ_G0033272
 protein coding gene Chr8:24418150-24429527 (-)
LP/J MGP_LPJ_G0033418
 protein coding gene Chr8:25568539-25579158 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033315
 protein coding gene Chr8:27118428-27130241 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034020
 protein coding gene Chr8:25436734-25448048 (-)
PWK/PhJ MGP_PWKPhJ_G0032236
 protein coding gene Chr8:24239032-24250092 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032069
 protein coding gene Chr8:24768433-24780599 (-)
WSB/EiJ MGP_WSBEiJ_G0032640
 protein coding gene Chr8:25624612-25636243 (-)



Homology
more
  • Human Ortholog
    CHRNA6, cholinergic receptor nicotinic alpha 6 subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNA6, cholinergic receptor nicotinic alpha 6 subunit
  • Synonyms
    CHNRA6
  • Links
    NCBI Gene ID: 8973
    neXtProt AC: NX_Q15825
    UniProt: Q15825

  • Chr Location
    8p11.21; chr8:42752620-42796392 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CHRNA6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homzygous mutant animals have decreased numbers of high affinity binding sites for [3H]nicotine, [3H]epibaditine, and [3H]cytisine in the terminal region of the retinal ganglion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    38
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11440 NCBI Gene Model | MGI Sequence Detail 10733 C57BL/6J ±  kb
    transcript NM_021369 RefSeq | MGI Sequence Detail 2921 Not Specified  
    polypeptide Q9R0W9 UniProt | EBI | MGI Sequence Detail 494 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005459 neuronal acetylcholine receptor subunit alpha-6
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    • GlyGen
      Q9R0W9 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33905
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:31397 Drescher DG, et al., Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Nov;112(3):267-73
    • Latest
      J:334616 Cooper SY, et al., Chemical Flavorants in Vaping Products Alter Neurobiology in a Sex-Dependent Manner to Promote Vaping-Related Behaviors. J Neurosci. 2023 Feb 22;43(8):1360-1374
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory