Pum3 MGI Mouse Gene Detail - MGI:106253 - pumilio RNA-binding family member 3

Symbol

Pum3
Name

pumilio RNA-binding family member 3
Synonyms

1110069H02Rik, D19Bwg1357e

Feature Type

protein coding gene
IDs

MGI:106253
NCBI Gene: 52874
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:27366098-27407225 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 21.96 cM
Mapping Data

3 experiments

SNPs within 2kb

1095 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106253	protein coding gene	Chr19:27366098-27407264 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025009	protein coding gene	Chr19:25755863-25792464 (-)
A/J	MGP_AJ_G0024986	protein coding gene	Chr19:24428334-24463632 (-)
AKR/J	MGP_AKRJ_G0024954	protein coding gene	Chr19:25349276-25384511 (-)
BALB/cJ	MGP_BALBcJ_G0024985	protein coding gene	Chr19:24467211-24503174 (-)
C3H/HeJ	MGP_C3HHeJ_G0024741	protein coding gene	Chr19:25308944-25347833 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025426	protein coding gene	Chr19:26497490-26533788 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022845	protein coding gene	Chr19:24444360-24479348 (-)
CAST/EiJ	MGP_CASTEiJ_G0024211	protein coding gene	Chr19:25086019-25121770 (-)
CBA/J	MGP_CBAJ_G0024719	protein coding gene	Chr19:27746831-27784643 (-)
DBA/2J	MGP_DBA2J_G0024851	protein coding gene	Chr19:24398801-24433923 (-)
FVB/NJ	MGP_FVBNJ_G0024813	protein coding gene	Chr19:24249220-24284388 (-)
LP/J	MGP_LPJ_G0024936	protein coding gene	Chr19:25737573-25778335 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024840	protein coding gene	Chr19:27667256-27702581 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025481	protein coding gene	Chr19:25345386-25387372 (-)
PWK/PhJ	MGP_PWKPhJ_G0023959	protein coding gene	Chr19:24039300-24074217 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023763	protein coding gene	Chr19:24567417-24604075 (-)
WSB/EiJ	MGP_WSBEiJ_G0024278	protein coding gene	Chr19:25363592-25400771 (-)

Human Ortholog

PUM3, pumilio RNA binding family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PUM3, pumilio RNA binding family member 3
Synonyms

HA-8, HLA-HA8, KIAA0020, PEN, PUF6, PUF-A, XTP5
Links

HGNC:29676

NCBI Gene ID: 9933

neXtProt AC: NX_Q15397

UniProt: Q15397
Chr Location

9p24.2; chr9:2720469-2844095 (-) GRCh38

MGI Vertebrate Homology

Pum3 stringent orthology
1 human;1 mouse;2 rat
HCOP

vertebrate homology predictions: PUM3
Gene Tree

Pum3

less

Phenotype Summary

10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

4
Gene trapped

12
Targeted

1
Transgenic

1
Genomic Mutations

1 involving Pum3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

Mice hemizygous for an inducible knockdown transgenic allele display loss of primordial germ cells.

less

All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

191
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pum3

ZFIN pum3

less

All Sequences

67
RefSeq

5
UniProt

6
CCDS

CCDS29723.1

Ensembl

ENSMUSG00000041360 (Evidence)
NCBI Gene

52874

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041360	Ensembl Gene Model \| MGI Sequence Detail	41128	C57BL/6J	± kb
transcript	ENSMUST00000076219	Ensembl \| MGI Sequence Detail	3471	Not Applicable
polypeptide	ENSMUSP00000075573	Ensembl \| MGI Sequence Detail	648	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000059783 pumilio homolog 3

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR012959 CPL domain

IPR040059 Pumilio homologue 3

IPR033133 Pumilio homology domain

IPR001313 Pumilio RNA-binding repeat

less

All nucleic 196

cDNA 194

Primer pair 2

Microarray probesets 5

less

MGD-MRK-33945, MGI:1916135, MGI:2147458

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 10
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:338852 Ko CF, et al., The Puf-A Protein Is Required for Primordial Germ Cell Development. Cells. 2022 Apr 27;11(9)

TSS for Pum3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158709	Chr19:27407207-27407270 (-)	-14 bp
Tssr158708	Chr19:27398781-27398827 (-)	8,421 bp
Tssr158707	Chr19:27376484-27376494 (-)	30,736 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24