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Tars1 Gene Detail
Summary
  • Symbol
    Tars1
  • Name
    threonyl-tRNA synthetase 1
  • Synonyms
    D15Wsu59e, Tars, ThrRS
  • Feature Type
    protein coding gene
  • IDs
    MGI:106314
    NCBI Gene: 110960
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:11383749-11399744 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.60 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    814 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106314
 protein coding gene Chr15:11382387-11399751 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021731
 protein coding gene Chr15:8569440-8585435 (-)
A/J MGP_AJ_G0021691
 protein coding gene Chr15:8302704-8318611 (-)
AKR/J MGP_AKRJ_G0021669
 protein coding gene Chr15:8514503-8530498 (-)
BALB/cJ MGP_BALBcJ_G0021698
 protein coding gene Chr15:8211726-8227701 (-)
C3H/HeJ MGP_C3HHeJ_G0021474
 protein coding gene Chr15:8470684-8486659 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022137
 protein coding gene Chr15:8886132-8902127 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019674
 protein coding gene Chr15:7773005-7788961 (-)
CAST/EiJ MGP_CASTEiJ_G0020990
 protein coding gene Chr15:8546205-8562200 (-)
CBA/J MGP_CBAJ_G0021443
 protein coding gene Chr15:9114371-9130364 (-)
DBA/2J MGP_DBA2J_G0021567
 protein coding gene Chr15:8176358-8192353 (-)
FVB/NJ MGP_FVBNJ_G0021545
 protein coding gene Chr15:8030573-8046785 (-)
LP/J MGP_LPJ_G0021635
 protein coding gene Chr15:8482391-8498362 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021570
 protein coding gene Chr15:9350136-9366109 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022160
 protein coding gene Chr15:8510156-8527227 (-)
PWK/PhJ MGP_PWKPhJ_G0020733
 protein coding gene Chr15:8351425-8368665 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020571
 protein coding gene Chr15:8456132-8473822 (-)
WSB/EiJ MGP_WSBEiJ_G0021046
 protein coding gene Chr15:8502465-8518460 (-)



Homology
more
  • Human Ortholog
    TARS1, threonyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TARS1, threonyl-tRNA synthetase 1
  • Synonyms
    TARS, ThrRS, TTD7
  • Links
    NCBI Gene ID: 6897
    neXtProt AC: NX_P26639
    UniProt: P26639

  • Chr Location
    5p13.3; chr5:33440696-33468091 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TARS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    929
  • Tissues
    113
  • cDNA Data
    190
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 110960 NCBI Gene Model | MGI Sequence Detail 15996 C57BL/6J ±  kb
transcript NM_033074 RefSeq | MGI Sequence Detail 2636 ZRU/MplStud  
polypeptide Q9D0R2 UniProt | EBI | MGI Sequence Detail 722 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016058 threonine--tRNA ligase 1, cytoplasmic
    (term hierarchy)
  • EC
    6.1.1.3
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
    IPR004154 Anticodon-binding
    IPR036621 Anticodon-binding domain superfamily
    IPR012675 Beta-grasp domain superfamily
    IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
    IPR004095 TGS
    IPR012676 TGS-like
    IPR033728 Threonine-tRNA ligase catalytic core domain
    IPR002320 Threonine-tRNA ligase, class IIa
    IPR047246 Threonine-tRNA ligase, class IIa, anticodon-binding domain
    IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
    IPR012947 Threonyl/alanyl tRNA synthetase, SAD
  • GlyGen
    Q9D0R2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 192
    cDNA 190
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-34006, MGI:7482292
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:341137 Zeng QY, et al., Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development. J Biol Chem. 2023 May;299(5):104704
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory