Med10 MGI Mouse Gene Detail - MGI:106331 - mediator complex subunit 10

Symbol

Med10
Name

mediator complex subunit 10
Synonyms

D13Wsu50e

Feature Type

protein coding gene
IDs

MGI:106331
NCBI Gene: 28077
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:69950514-69964223 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 35.55 cM
Mapping Data

4 experiments

SNPs within 2kb

558 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106331	protein coding gene	Chr13:69950467-69964223 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020735	protein coding gene	Chr13:70097032-70103245 (+)
A/J	MGP_AJ_G0020691	protein coding gene	Chr13:67597655-67603835 (+)
AKR/J	MGP_AKRJ_G0020666	protein coding gene	Chr13:69818024-69824204 (+)
BALB/cJ	MGP_BALBcJ_G0020688	protein coding gene	Chr13:68121164-68127344 (+)
C3H/HeJ	MGP_C3HHeJ_G0020483	protein coding gene	Chr13:69481243-69487423 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021125	protein coding gene	Chr13:72500788-72506996 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018693	protein coding gene	Chr13:64548487-64554695 (+)
CAST/EiJ	MGP_CASTEiJ_G0020000	protein coding gene	Chr13:68487920-68494468 (+)
CBA/J	MGP_CBAJ_G0020441	protein coding gene	Chr13:75297126-75303306 (+)
DBA/2J	MGP_DBA2J_G0020567	protein coding gene	Chr13:67487946-67494126 (+)
FVB/NJ	MGP_FVBNJ_G0020547	protein coding gene	Chr13:66491014-66499669 (+)
LP/J	MGP_LPJ_G0020639	protein coding gene	Chr13:70388044-70394223 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020575	protein coding gene	Chr13:73732467-73738647 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021164	protein coding gene	Chr13:69086158-69092338 (+)
PWK/PhJ	MGP_PWKPhJ_G0019754	protein coding gene	Chr13:66187597-66193946 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019577	protein coding gene	Chr13:65598086-65604372 (+)
WSB/EiJ	MGP_WSBEiJ_G0020057	protein coding gene	Chr13:69579120-69585341 (+)

Human Ortholog

MED10, mediator complex subunit 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MED10, mediator complex subunit 10
Synonyms

L6, NUT2, TRG20
Links

HGNC:28760

NCBI Gene ID: 84246

neXtProt AC: NX_Q9BTT4

UniProt: Q9BTT4
Chr Location

5p15.31; chr5:6371874-6378571 (-) GRCh38

MGI Vertebrate Homology

Med10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MED10
Gene Tree

Med10

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Genomic Mutations

1 involving Med10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

3
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase med10

ZFIN med10

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All Sequences

58
RefSeq

6
UniProt

4
CCDS

CCDS26625.1

Ensembl

ENSMUSG00000021598 (Evidence)
NCBI Gene

28077

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021598	Ensembl Gene Model \| MGI Sequence Detail	13710	C57BL/6J	± kb
transcript	ENSMUST00000221893	Ensembl \| MGI Sequence Detail	815	Not Applicable
polypeptide	ENSMUSP00000152144	Ensembl \| MGI Sequence Detail	154	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010280 mediator of RNA polymerase II transcription subunit 10

(term hierarchy)
PDB

6W1S, 8T1I, 8T1L
InterPro Domains

IPR019145 Mediator complex, subunit Med10

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All nucleic 15

cDNA 13

Primer pair 2

Microarray probesets 3

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MGD-MRK-34023, MGI:2145175, MGI:2145222, MGI:2145500

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563

TSS for Med10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120283	Chr13:69950481-69950507 (+)	-20 bp
Tssr120284	Chr13:69950509-69950524 (+)	3 bp
Tssr120285	Chr13:69957967-69957978 (+)	7,459 bp
Tssr120286	Chr13:69957982-69958018 (+)	7,486 bp
Tssr120287	Chr13:69958278-69958291 (+)	7,771 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24