Rcor1 MGI Mouse Gene Detail - MGI:106340

Symbol

Rcor1
Name

REST corepressor 1
Synonyms

6720480E22Rik, D12Wsu95e, mKIAA0071, Rocr1

Feature Type

protein coding gene
IDs

MGI:106340
NCBI Gene: 217864
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:111005801-111082336 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 60.93 cM
Mapping Data

7 experiments

SNPs within 2kb

1796 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106340	protein coding gene	Chr12:111005785-111082336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020126	protein coding gene	Chr12:113396542-113478511 (+)
A/J	MGP_AJ_G0020082	protein coding gene	Chr12:109046140-109126418 (+)
AKR/J	MGP_AKRJ_G0020057	protein coding gene	Chr12:112169758-112247597 (+)
BALB/cJ	MGP_BALBcJ_G0020067	protein coding gene	Chr12:109462696-109542066 (+)
C3H/HeJ	MGP_C3HHeJ_G0019869	protein coding gene	Chr12:112641491-112723121 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020512	protein coding gene	Chr12:116923292-117000134 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018125	protein coding gene	Chr12:105494049-105568596 (+)
CAST/EiJ	MGP_CASTEiJ_G0019410	protein coding gene	Chr12:107526304-107606277 (+)
CBA/J	MGP_CBAJ_G0019836	protein coding gene	Chr12:121414667-121504066 (+)
DBA/2J	MGP_DBA2J_G0019953	protein coding gene	Chr12:108532625-108611663 (+)
FVB/NJ	MGP_FVBNJ_G0019938	protein coding gene	Chr12:107322037-107400820 (+)
LP/J	MGP_LPJ_G0020028	protein coding gene	Chr12:113210354-113283116 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019976	protein coding gene	Chr12:124523737-124612594 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020541	protein coding gene	Chr12:111660163-111752903 (+)
PWK/PhJ	MGP_PWKPhJ_G0019171	protein coding gene	Chr12:103159333-103240867 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018974	protein coding gene	Chr12:105843443-105920740 (+)
WSB/EiJ	MGP_WSBEiJ_G0019469	protein coding gene	Chr12:112602152-112684278 (+)

Human Ortholog

RCOR1, REST corepressor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RCOR1, REST corepressor 1
Synonyms

COREST, RCOR
Links

HGNC:17441

NCBI Gene ID: 23186

neXtProt AC: NX_Q9UKL0

UniProt: Q9UKL0
Chr Location

14q32.31-q32.32; chr14:102592649-102730561 (+) GRCh38

MGI Vertebrate Homology

Rcor1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RCOR1
Gene Tree

Rcor1

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

2
Gene trapped

15
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available

Mice homozygous for a null allele exhibit partial embryonic lethality, defective embryonic erythropoiesis, and decreased erythroid progenitor cell number. No homozygotes survive to P7.

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All GO Annotations

28
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

24
cDNA Data

18
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RCOR1

Xenbase rcor1

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All Sequences

44
RefSeq

2
UniProt

2
CCDS

CCDS49179.2

Ensembl

ENSMUSG00000037896 (Evidence)
NCBI Gene

217864

			Length	Strain/Species	Flank
genomic	217864	NCBI Gene Model \| MGI Sequence Detail	76536	C57BL/6J	± kb
transcript	NM_198023	RefSeq \| MGI Sequence Detail	5669	ZRU/MplStud
polypeptide	Q8CFE3	UniProt \| EBI \| MGI Sequence Detail	480	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013841 REST corepressor 1

(term hierarchy)
InterPro Domains

IPR000949 ELM2 domain

IPR009057 Homeobox-like domain superfamily

IPR049048 REST corepressor, helical domain

IPR017884 SANT domain

IPR001005 SANT/Myb domain

IPR051066 Transcriptional Regulator and Corepressor
GlyGen

Q8CFE3 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 19

Primer pair 3

Microarray probesets 7

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MGD-MRK-34032, MGI:2144964, MGI:2441723

Summaries

All 60

Developmental Gene Expression 13

Gene Ontology 13

Phenotypes 11
Earliest

J:37953 Lan Y, et al., The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mamm Genome. 1997;8(11):875-6
Latest

J:327434 Ramirez M, et al., Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions. Elife. 2022 Aug 9;11:e74207

TSS for Rcor1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115244	Chr12:111005768-111005834 (+)	0 bp
Tssr115245	Chr12:111007267-111007273 (+)	1,469 bp
Tssr115246	Chr12:111034325-111034347 (+)	28,535 bp
Tssr115247	Chr12:111042941-111042945 (+)	37,142 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24