Vps25 MGI Mouse Gene Detail - MGI:106354 - vacuolar protein sorting 25

Symbol

Vps25
Name

vacuolar protein sorting 25
Synonyms

1110020N13Rik, D11Wsu68e

Feature Type

protein coding gene
IDs

MGI:106354
NCBI Gene: 28084
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:101144533-101150375 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 64.48 cM
Mapping Data

4 experiments

SNPs within 2kb

184 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106354	protein coding gene	Chr11:101144533-101150377 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019189	protein coding gene	Chr11:104094534-104102694 (+)
A/J	MGP_AJ_G0019157	protein coding gene	Chr11:99719867-99726629 (+)
AKR/J	MGP_AKRJ_G0019126	protein coding gene	Chr11:102817968-102823736 (+)
BALB/cJ	MGP_BALBcJ_G0019131	protein coding gene	Chr11:100207215-100213014 (+)
C3H/HeJ	MGP_C3HHeJ_G0018940	protein coding gene	Chr11:102991474-102997779 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019580	protein coding gene	Chr11:107325320-107338135 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017206	protein coding gene	Chr11:97134418-97140095 (+)
CAST/EiJ	MGP_CASTEiJ_G0018494	protein coding gene	Chr11:103980402-103986614 (+)
CBA/J	MGP_CBAJ_G0018909	protein coding gene	Chr11:111773133-111780626 (+)
DBA/2J	MGP_DBA2J_G0019021	protein coding gene	Chr11:99247088-99253562 (+)
FVB/NJ	MGP_FVBNJ_G0019011	protein coding gene	Chr11:98794297-98800310 (+)
LP/J	MGP_LPJ_G0019090	protein coding gene	Chr11:104640570-104647652 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019042	protein coding gene	Chr11:111339358-111346308 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019618	protein coding gene	Chr11:103144432-103153347 (+)
PWK/PhJ	MGP_PWKPhJ_G0018257	protein coding gene	Chr11:100304056-100309729 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018049	protein coding gene	Chr11:102884556-102890593 (+)
WSB/EiJ	MGP_WSBEiJ_G0018543	protein coding gene	Chr11:103140559-103146383 (+)

Human Ortholog

VPS25, vacuolar protein sorting 25 homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VPS25, vacuolar protein sorting 25 homolog
Synonyms

DERP9, EAP20, FAP20
Links

HGNC:28122

NCBI Gene ID: 84313

neXtProt AC: NX_Q9BRG1

UniProt: Q9BRG1
Chr Location

17q21.2; chr17:42773449-42779599 (+) GRCh38

MGI Vertebrate Homology

Vps25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VPS25
Gene Tree

Vps25

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Phenotype Summary

23 phenotypes from 3 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (ENU)

1
Targeted

4
Genomic Mutations

1 involving Vps25
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality before E8.5. Mice homozygous for a hypomorphic allele exhibit short limbs, polydactyly and craniofacial defects.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

45
cDNA Data

161
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vps25

ZFIN vps25

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All Sequences

71
RefSeq

8
UniProt

5
CCDS

CCDS25458.1, CCDS70311.1, CCDS70312.1, CCDS70313.1

Ensembl

ENSMUSG00000078656 (Evidence)
NCBI Gene

28084

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078656	Ensembl Gene Model \| MGI Sequence Detail	5843	C57BL/6J	± kb
transcript	ENSMUST00000107280	Ensembl \| MGI Sequence Detail	876	Not Applicable
polypeptide	ENSMUSP00000102901	Ensembl \| MGI Sequence Detail	184	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017326 vacuolar protein-sorting-associated protein 25

(term hierarchy)
InterPro Domains

IPR008570 ESCRT-II complex, Vps25 subunit

IPR014041 ESCRT-II complex, Vps25 subunit, N-terminal winged helix

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 164

cDNA 161

Primer pair 3

Microarray probesets 5

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MGD-MRK-34046, MGI:1915833, MGI:2144496

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 13
Earliest

J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vps25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105064	Chr11:101144399-101144420 (+)	-123 bp
Tssr105065	Chr11:101144546-101144583 (+)	32 bp
Tssr105066	Chr11:101146544-101146550 (+)	2,014 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24