Grsf1 MGI Mouse Gene Detail - MGI:106479 - G-rich RNA sequence binding factor 1

Symbol

Grsf1
Name

G-rich RNA sequence binding factor 1
Synonyms

D5Wsu31e

Feature Type

protein coding gene
IDs

MGI:106479
NCBI Gene: 231413
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr5:88807307-88824030 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.85 cM
Mapping Data

3 experiments

SNPs within 2kb

408 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106479	protein coding gene	Chr5:88807092-88824030 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029711	protein coding gene	Chr5:89661907-89680789 (-)
A/J	MGP_AJ_G0029677	protein coding gene	Chr5:86121411-86146557 (-)
AKR/J	MGP_AKRJ_G0029623	protein coding gene	Chr5:88959267-88978141 (-)
BALB/cJ	MGP_BALBcJ_G0029687	protein coding gene	Chr5:87030273-87048514 (-)
C3H/HeJ	MGP_C3HHeJ_G0029410	protein coding gene	Chr5:89305796-89324319 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030141	protein coding gene	Chr5:93297373-93316313 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027377	protein coding gene	Chr5:81931863-81948399 (-)
CAST/EiJ	MGP_CASTEiJ_G0028820	protein coding gene	Chr5:88726170-88746569 (-)
CBA/J	MGP_CBAJ_G0029379	protein coding gene	Chr5:96418845-96439200 (-)
DBA/2J	MGP_DBA2J_G0029524	protein coding gene	Chr5:86190177-86207160 (-)
FVB/NJ	MGP_FVBNJ_G0029483	protein coding gene	Chr5:85107276-85126598 (-)
LP/J	MGP_LPJ_G0029612	protein coding gene	Chr5:90062396-90081670 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029512	protein coding gene	Chr5:101443306-101463433 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030175	protein coding gene	Chr5:88474780-88495547 (-)
PWK/PhJ	MGP_PWKPhJ_G0028539	protein coding gene	Chr5:85271037-85290305 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028374	protein coding gene	Chr5:87898050-87919632 (-)
WSB/EiJ	MGP_WSBEiJ_G0028899	protein coding gene	Chr5:88862836-88882050 (-)

Human Ortholog

GRSF1, G-rich RNA sequence binding factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRSF1, G-rich RNA sequence binding factor 1
Links

HGNC:4610

NCBI Gene ID: 2926

neXtProt AC: NX_Q12849

UniProt: Q12849
Chr Location

4q13.3; chr4:70815783-70843235 (-) GRCh38

MGI Vertebrate Homology

Grsf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRSF1
Gene Tree

Grsf1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

1
Spontaneous

1
Targeted

5
Genomic Mutations

4 involving Grsf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

63
cDNA Data

125
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grsf1

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All Sequences

66
RefSeq

4
UniProt

6
CCDS

CCDS19404.1, CCDS51540.1

Ensembl

ENSMUSG00000044221 (Evidence)
NCBI Gene

231413

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044221	Ensembl Gene Model \| MGI Sequence Detail	16724	C57BL/6J	± kb
transcript	ENSMUST00000078945	Ensembl \| MGI Sequence Detail	2538	Not Applicable
polypeptide	ENSMUSP00000077972	Ensembl \| MGI Sequence Detail	479	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008275 G-rich sequence factor 1

(term hierarchy)
InterPro Domains

IPR050666 Epithelial Splicing Regulatory

IPR034425 GRSF-1, RNA recognition motif 1

IPR034424 GRSF-1, RNA recognition motif 2

IPR034426 GRSF-1, RNA recognition motif 3

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q8C5Q4 1 site, 1 O-linked glycan (1 site)

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All nucleic 128

cDNA 125

Primer pair 3

Microarray probesets 5

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MGD-MRK-34173, MGI:2141317, MGI:3035110

Summaries

All 55

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Grsf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51696	Chr5:88824085-88824096 (-)	-61 bp
Tssr51695	Chr5:88824051-88824068 (-)	-30 bp
Tssr51694	Chr5:88823994-88824045 (-)	10 bp
Tssr51693	Chr5:88823970-88823988 (-)	51 bp
Tssr51692	Chr5:88823472-88823514 (-)	537 bp
Tssr51691	Chr5:88823424-88823451 (-)	592 bp
Tssr51690	Chr5:88823401-88823422 (-)	618 bp
Tssr51689	Chr5:88823049-88823086 (-)	962 bp
Tssr51688	Chr5:88818065-88818115 (-)	5,940 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24