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Plppr4 Gene Detail
Summary
  • Symbol
    Plppr4
  • Name
    phospholipid phosphatase related 4
  • Synonyms
    D3Bwg0562e, Lppr4, mKIAA0455, PRG-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106530
    NCBI Gene: 229791
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:117112794-117154525 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 50.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106530
 protein coding gene Chr3:117112788-117154525 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027822
 protein coding gene Chr3:119295871-119338190 (-)
A/J MGP_AJ_G0027780
 protein coding gene Chr3:115364330-115406678 (-)
AKR/J MGP_AKRJ_G0027746
 protein coding gene Chr3:118276352-118318346 (-)
BALB/cJ MGP_BALBcJ_G0027792
 protein coding gene Chr3:115206208-115247506 (-)
C3H/HeJ MGP_C3HHeJ_G0027523
 protein coding gene Chr3:118658437-118707184 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028238
 protein coding gene Chr3:123650979-123693955 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025577
 protein coding gene Chr3:111007729-111049689 (-)
CAST/EiJ MGP_CASTEiJ_G0026979
 protein coding gene Chr3:117948401-117992952 (-)
CBA/J MGP_CBAJ_G0027498
 protein coding gene Chr3:127895172-127943172 (-)
DBA/2J MGP_DBA2J_G0027639
 protein coding gene Chr3:114581472-114624134 (-)
FVB/NJ MGP_FVBNJ_G0027607
 protein coding gene Chr3:112204949-112245496 (-)
LP/J MGP_LPJ_G0027749
 protein coding gene Chr3:120818070-120866825 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027637
 protein coding gene Chr3:135279789-135326412 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028294
 protein coding gene Chr3:117825252-117870237 (-)
PWK/PhJ MGP_PWKPhJ_G0026705
 protein coding gene Chr3:114232789-114276425 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026527
 protein coding gene Chr3:115837056-115884638 (-)
WSB/EiJ MGP_WSBEiJ_G0027059
 protein coding gene Chr3:118532898-118580071 (-)



Homology
more
  • Human Ortholog
    PLPPR4, phospholipid phosphatase related 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLPPR4, phospholipid phosphatase related 4
  • Synonyms
    LPPR4, LPR4, PHP1, PRG-1, PRG1
  • Links
    NCBI Gene ID: 9890
    neXtProt AC: NX_Q7Z2D5
    UniProt: Q7Z2D5

  • Chr Location
    1p21.3-p21.2; chr1:99262924-99309590 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 1 genetic background
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced body weight, seizures, hyperexcitability of evoked fEPSP, and premature lethality around 3 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    26
  • cDNA Data
    23
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 229791 NCBI Gene Model | MGI Sequence Detail 41732 C57BL/6J ±  kb
    transcript NM_177664 RefSeq | MGI Sequence Detail 5690 Not Specified  
    polypeptide Q7TME0 UniProt | EBI | MGI Sequence Detail 766 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000009906 phospholipid phosphatase-related protein type 4
      (term hierarchy)
    • InterPro Domains
      IPR043216 Phosphatidate (PA) phosphatase-related
      IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
      IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
    • GlyGen
      Q7TME0 11 sites, 2 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34224
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:339777 Knierim E, et al., Mutations in plasticity-related-gene-1 (PRG-1) protein contribute to hippocampal seizure susceptibility and modify epileptic phenotype. Cereb Cortex. 2023 Jun 8;33(12):7454-7467
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory