About   Help   FAQ
Spout1 Gene Detail
Summary
  • Symbol
    Spout1
  • Name
    SPOUT domain containing methyltransferase 1
  • Synonyms
    D2Wsu81e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106544
    NCBI Gene: 227695
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30063465-30068471 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106544
 protein coding gene Chr2:30063458-30068506 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025557
 protein coding gene Chr2:28394502-28399508 (-)
A/J MGP_AJ_G0025535
 protein coding gene Chr2:27257915-27262921 (-)
AKR/J MGP_AKRJ_G0025504
 protein coding gene Chr2:28186405-28191411 (-)
BALB/cJ MGP_BALBcJ_G0025531
 protein coding gene Chr2:27386220-27391226 (-)
C3H/HeJ MGP_C3HHeJ_G0025292
 protein coding gene Chr2:28114596-28119602 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025976
 protein coding gene Chr2:29330225-29335231 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023384
 protein coding gene Chr2:26050332-26055321 (-)
CAST/EiJ MGP_CASTEiJ_G0024754
 protein coding gene Chr2:28006828-28011828 (-)
CBA/J MGP_CBAJ_G0025269
 protein coding gene Chr2:30323610-30328616 (-)
DBA/2J MGP_DBA2J_G0025402
 protein coding gene Chr2:27042922-27047928 (-)
FVB/NJ MGP_FVBNJ_G0025365
 protein coding gene Chr2:26859401-26864407 (-)
LP/J MGP_LPJ_G0025488
 protein coding gene Chr2:28300569-28305575 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025395
 protein coding gene Chr2:30219709-30224715 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026034
 protein coding gene Chr2:28100208-28105214 (-)
PWK/PhJ MGP_PWKPhJ_G0024501
 protein coding gene Chr2:26887325-26892325 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024301
 protein coding gene Chr2:28193521-28198537 (-)
WSB/EiJ MGP_WSBEiJ_G0024822
 protein coding gene Chr2:28232596-28237604 (-)



Homology
more
  • Human Ortholog
    SPOUT1, SPOUT domain containing methyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPOUT1, SPOUT domain containing methyltransferase 1
  • Synonyms
    C9orf114, CENP-32, CENP32, HSPC109
  • Links
    NCBI Gene ID: 51490
    neXtProt AC: NX_Q5T280
    UniProt: Q5T280

  • Chr Location
    9q34.11; chr9:128819651-128829794 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality before implantation. Heterozygotes show reduced spontaneous apoptosis of differentiating spermatogonia as well as reduced apoptosis and nuclear DNA fragmentation in splenocytes, thymocytes and MEFs in response to apoptotic stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    2
  • cDNA Data
    12
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039660 Ensembl Gene Model | MGI Sequence Detail 5007 C57BL/6J ±  kb
transcript ENSMUST00000100220 Ensembl | MGI Sequence Detail 1805 Not Applicable  
polypeptide ENSMUSP00000097793 Ensembl | MGI Sequence Detail 385 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-34238, MGI:2139144
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory