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Tsg101 Gene Detail
Summary
  • Symbol
    Tsg101
  • Name
    tumor susceptibility gene 101
  • Synonyms
    CC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106581
    NCBI Gene: 22088
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46538697-46569717 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.62 cM, cytoband B5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    797 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106581
 protein coding gene Chr7:46538693-46569717 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032276
 protein coding gene Chr7:47295312-47328314 (-)
A/J MGP_AJ_G0032255
 protein coding gene Chr7:46314480-46345863 (-)
AKR/J MGP_AKRJ_G0032191
 protein coding gene Chr7:47629524-47660465 (-)
BALB/cJ MGP_BALBcJ_G0032267
 protein coding gene Chr7:46318531-46352963 (-)
C3H/HeJ MGP_C3HHeJ_G0031980
 protein coding gene Chr7:48104050-48135964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032757
 protein coding gene Chr7:49564050-49597893 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029773
 protein coding gene Chr7:48855099-48886728 (-)
CAST/EiJ MGP_CASTEiJ_G0031308
 protein coding gene Chr7:39573186-39607769 (-)
CBA/J MGP_CBAJ_G0031945
 protein coding gene Chr7:51231938-51265328 (-)
DBA/2J MGP_DBA2J_G0032102
 protein coding gene Chr7:45991781-46022916 (-)
FVB/NJ MGP_FVBNJ_G0032056
 protein coding gene Chr7:45806945-45839201 (-)
LP/J MGP_LPJ_G0032183
 protein coding gene Chr7:48008672-48041066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032093
 protein coding gene Chr7:49848771-49881567 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032774
 protein coding gene Chr7:46830540-46863482 (-)
PWK/PhJ MGP_PWKPhJ_G0031033
 protein coding gene Chr7:39373355-39405556 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030871
 protein coding gene Chr7:34856257-34885818 (-)
WSB/EiJ MGP_WSBEiJ_G0031428
 protein coding gene Chr7:47351168-47386058 (-)



Homology
more
  • Human Ortholog
    TSG101, tumor susceptibility 101
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSG101, tumor susceptibility 101
  • Synonyms
    TSG10, VPS23
  • Links
    NCBI Gene ID: 7251
    neXtProt AC: NX_Q99816
    UniProt: Q99816

  • Chr Location
    11p15.1; chr11:18468336-18526951 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human TSG101 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced growth, fail to form mesoderm, accumulate p53 protein and die by embryonic day 6.5. Homozygotes for a mammary gland-specific knockout show impaired mammogenesis and are unable to nurse their pups.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    74
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    56
  • cDNA Data
    130
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014402 Ensembl Gene Model | MGI Sequence Detail 31021 C57BL/6J ±  kb
    transcript ENSMUST00000014546 Ensembl | MGI Sequence Detail 1949 Not Applicable  
    polypeptide ENSMUSP00000014546 Ensembl | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      Genomic 1
      cDNA 130
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35037, MGI:2141888
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 9
      Gene Ontology 16
      Phenotypes 19
    • Earliest
      J:51752 Maucuer A, et al., Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3100-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory