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Neurod6 Gene Detail
Summary
  • Symbol
    Neurod6
  • Name
    neurogenic differentiation 6
  • Synonyms
    Atoh2, bHLHa2, Math-2, Math2, Nex, Nex1m
  • Feature Type
    protein coding gene
  • IDs
    MGI:106593
    NCBI Gene: 11922
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:55654807-55658248 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106593
 protein coding gene Chr6:55654803-55658248 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030775
 protein coding gene Chr6:55095293-55098742 (-)
A/J MGP_AJ_G0030744
 protein coding gene Chr6:52533597-52537038 (-)
AKR/J MGP_AKRJ_G0030671
 protein coding gene Chr6:54311162-54314603 (-)
BALB/cJ MGP_BALBcJ_G0030756
 protein coding gene Chr6:52915829-52919270 (-)
C3H/HeJ MGP_C3HHeJ_G0030469
 protein coding gene Chr6:54344542-54347985 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031211
 protein coding gene Chr6:56320547-56323976 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028417
 protein coding gene Chr6:50139554-50142998 (-)
CAST/EiJ MGP_CASTEiJ_G0029872
 protein coding gene Chr6:54206368-54209819 (-)
CBA/J MGP_CBAJ_G0030443
 protein coding gene Chr6:58613124-58616565 (-)
DBA/2J MGP_DBA2J_G0030593
 protein coding gene Chr6:52433004-52436445 (-)
FVB/NJ MGP_FVBNJ_G0030545
 protein coding gene Chr6:52033454-52036895 (-)
LP/J MGP_LPJ_G0030678
 protein coding gene Chr6:55021577-55025026 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030579
 protein coding gene Chr6:61119550-61122991 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031241
 protein coding gene Chr6:54286359-54289806 (-)
PWK/PhJ MGP_PWKPhJ_G0029585
 protein coding gene Chr6:52102354-52105871 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029419
 protein coding gene Chr6:53666735-53670175 (-)
WSB/EiJ MGP_WSBEiJ_G0029949
 protein coding gene Chr6:54325149-54328589 (-)



Homology
more
  • Human Ortholog
    NEUROD6, neuronal differentiation 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROD6, neuronal differentiation 6
  • Synonyms
    Atoh2, bHLHa2, Math-2, MATH2, Nex1, NEX1M
  • Links
    NCBI Gene ID: 63974
    neXtProt AC: NX_Q96NK8
    UniProt: Q96NK8

  • Chr Location
    7p14.3; chr7:31337465-31340726 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    70 phenotypes from multigenic genotypes
    338 phenotype references
Mice homozygous for a targeted null mutation are viable and fertile and exhibit an apparently normal differentiation of CNS neurons with no obvious behavioral or motor abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1182
  • Tissues
    272
  • cDNA Data
    21
  • Literature Summary
    76
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037984 Ensembl Gene Model | MGI Sequence Detail 3442 C57BL/6J ±  kb
transcript ENSMUST00000044767 Ensembl | MGI Sequence Detail 2150 Not Applicable  
polypeptide ENSMUSP00000047016 Ensembl | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011155 neurogenic differentiation factor 6
    (term hierarchy)
  • InterPro Domains
    IPR050359 Basic helix-loop-helix transcription factors
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR022575 Neurogenic differentiation factor, domain of unknown function
    IPR016637 Neurogenic differentiation factor NeuroD
Molecular
Reagents
less
  • All nucleic 38
    Genomic 2
    cDNA 22
    Primer pair 8
    Other 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35049
References
more
  • Summaries
    All 440
    Developmental Gene Expression 76
    Diseases 1
    Gene Ontology 6
    Phenotypes 338
  • Earliest
    J:33073 Bartholoma A, et al., NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev. 1994 Dec;48(3):217-28
  • Latest
    J:354981 Loganathan S, et al., Cacna1c deficiency in forebrain glutamatergic neurons alters behavior and hippocampal plasticity in female mice. Transl Psychiatry. 2024 Oct 6;14(1):421
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory