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Myo5b Gene Detail
Summary
  • Symbol
    Myo5b
  • Name
    myosin VB
  • Feature Type
    protein coding gene
  • IDs
    MGI:106598
    NCBI Gene: 17919
  • Alliance
    genome feature page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:74575435-74905769 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 50.70 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11897 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106598
 protein coding gene Chr18:74574007-74905769 (+)
129S1/SvImJ ENSMUSG00200026472
 protein coding gene Chr18:71800412-72116503 (+)
A/J ENSMUSG00195004766
 protein coding gene Chr18:71857463-72188362 (+)
AKR/J ENSMUSG00220016982
 protein coding gene Chr18:71787186-72108517 (+)
BALB/cJ ENSMUSG00180013207
 protein coding gene Chr18:72434012-72764915 (+)
C3H/HeJ ENSMUSG00175012410
 protein coding gene Chr18:71993819-72317059 (+)
C57BL/6NJ ENSMUSG00215018541
 protein coding gene Chr18:71336850-71667773 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022401
 protein coding gene Chr18:70866069-71181933 (+)
CAST/EiJ ENSTCUG00005027104
 protein coding gene Chr18:70912549-71228463 (+)
CBA/J ENSMUSG00210033203
 protein coding gene Chr18:71951310-72274549 (+)
DBA/2J ENSMUSG00185010683
 protein coding gene Chr18:71857480-72180727 (+)
FVB/NJ ENSMUSG00205012094
 protein coding gene Chr18:71468878-71790215 (+)
JF1/MsJ ENSUMUG00000026009
 protein coding gene Chr18:71769482-72090909 (+)
LP/J ENSMUSG00230011013
 protein coding gene Chr18:73924556-74239991 (+)
NOD/ShiLtJ ENSMUSG00190020550
 protein coding gene Chr18:71602996-71933894 (+)
NZO/HlLtJ ENSMUSG00225033519
 protein coding gene Chr18:73773997-74091524 (+)
PWK/PhJ ENSLUMG00010006214
 protein coding gene Chr18:72187793-72501811 (+)
SPRET/EiJ ENSMSPG00010008599
 protein coding gene Chr18:72424593-72739737 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MYO5B, myosin VB
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO5B, myosin VB
  • Synonyms
    DIAR2, MVID1, PFIC10
  • Links
    NCBI Gene ID: 4645
    UniProt: Q9ULV0

  • Chr Location
    18q21.1; chr18:49822789-50195164 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Myo5b mouse models; 2 with human MYO5B associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show perinatal mortality, diarrhea, intestinal microvillus atrophy and the presence of microvillus inclusion bodies, resembling phenotype of Microvillus Inclusion Disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    56
  • cDNA Data
    48
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17919 NCBI Gene Model | MGI Sequence Detail 330335 C57BL/6J ±  kb
    transcript NM_201600 RefSeq | MGI Sequence Detail 6647 ZRU/MplStud  
    polypeptide P21271 UniProt | EBI | MGI Sequence Detail 1818 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 53
      Primer pair 2
      Antibodies 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-35054, MGI:2147254
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 12
      Phenotypes 23
    • Earliest
      J:36578 Huang WM, et al., Molecular cloning and amino acid sequence of brain L-glutamate decarboxylase. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8491-5
    • Latest
      J:384977 McKee PR, et al., Myosin 5b deficiency alters liver proliferation, zonation, and bile acid composition. Hepatol Commun. 2026 Mar 1;10(3):e00899
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory