Gpx2 MGI Mouse Gene Detail - MGI:106609 - glutathione peroxidase 2

Symbol

Gpx2
Name

glutathione peroxidase 2
Synonyms

GI-GPx, GPx-GI, intestinal GPx

Feature Type

protein coding gene
IDs

MGI:106609
NCBI Gene: 14776
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:76839107-76842273 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 33.73 cM
Mapping Data

6 experiments

SNPs within 2kb

191 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106609	protein coding gene	Chr12:76839107-76842328 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019865	protein coding gene	Chr12:76918789-76922000 (-)
A/J	MGP_AJ_G0019823	protein coding gene	Chr12:73988618-73991839 (-)
AKR/J	MGP_AKRJ_G0019798	protein coding gene	Chr12:76230368-76233587 (-)
BALB/cJ	MGP_BALBcJ_G0019802	protein coding gene	Chr12:74460941-74464158 (-)
C3H/HeJ	MGP_C3HHeJ_G0019608	protein coding gene	Chr12:76695932-76699153 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020254	protein coding gene	Chr12:79272407-79275749 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017872	protein coding gene	Chr12:71331518-71334693 (-)
CAST/EiJ	MGP_CASTEiJ_G0019159	protein coding gene	Chr12:71507856-71511060 (-)
CBA/J	MGP_CBAJ_G0019578	protein coding gene	Chr12:82340640-82343861 (-)
DBA/2J	MGP_DBA2J_G0019694	protein coding gene	Chr12:73861953-73865170 (-)
FVB/NJ	MGP_FVBNJ_G0019681	protein coding gene	Chr12:72684361-72687790 (-)
LP/J	MGP_LPJ_G0019766	protein coding gene	Chr12:76892737-76895948 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019720	protein coding gene	Chr12:85346490-85349709 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020290	protein coding gene	Chr12:75718638-75721859 (-)
PWK/PhJ	MGP_PWKPhJ_G0018925	protein coding gene	Chr12:68201885-68205162 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018719	protein coding gene	Chr12:70218114-70221343 (-)
WSB/EiJ	MGP_WSBEiJ_G0019211	protein coding gene	Chr12:76325918-76329133 (-)

Human Ortholog

GPX2, glutathione peroxidase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPX2, glutathione peroxidase 2
Synonyms

GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPx-2, GSHPX-GI
Links

HGNC:4554

NCBI Gene ID: 2877

neXtProt AC: NX_P18283

UniProt: P18283
Chr Location

14q23.3; chr14:64939152-64942746 (-) GRCh38

MGI Vertebrate Homology

Gpx2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPX2
Protein SuperFamily

Glutathion_perox
Gene Tree

Gpx2

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 2 alleles in 1 genetic background
15 phenotypes from multigenic genotypes
24 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Gpx2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available

Homozygotes for a targeted null allele appear normal, but double knockouts of Gpx1 and Gpx2 exhibit symptoms of inflammatory bowel disease, including perianal ulceration, growth retardation, and hypothermia, a condition that is sometimes fatal not observed in either single knockout.

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All GO Annotations

24
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1115
Tissues

288
cDNA Data

11
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpx2

ZFIN gpx2

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS25996.1

Ensembl

ENSMUSG00000042808 (Evidence)
NCBI Gene

14776

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042808	Ensembl Gene Model \| MGI Sequence Detail	3167	C57BL/6J	± kb
transcript	ENSMUST00000082431	Ensembl \| MGI Sequence Detail	1010	Not Applicable
polypeptide	ENSMUSP00000081012	Ensembl \| MGI Sequence Detail	190	Not Applicable

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UniProt

2 Sequences
EC

1.11.1.12, 1.11.1.9
InterPro Domains

IPR000889 Glutathione peroxidase

IPR029759 Glutathione peroxidase active site

IPR029760 Glutathione peroxidase conserved site

IPR036249 Thioredoxin-like superfamily

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All nucleic 18

Genomic 2

cDNA 13

Primer pair 3

Microarray probesets 2

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MGD-MRK-35066

Summaries

All 64

Developmental Gene Expression 11

Diseases 1

Gene Ontology 11

Phenotypes 24
Earliest

J:32889 Chu FF, et al., The mouse glutathione peroxidase Gpx2 gene maps to chromosome 12; its pseudogene Gpx2-ps maps to chromosome 7. Genomics. 1996 May 1;33(3):516-8
Latest

J:259708 Lennicke C, et al., Loss of epithelium-specific GPx2 results in aberrant cell fate decisions during intestinal differentiation. Oncotarget. 2018 Jan 2;9(1):539-552

TSS for Gpx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3866	Chr12:76842323-76842326 (-)	-52 bp
Tssr116754	Chr12:76842263-76842295 (-)	-6 bp
Tssr116753	Chr12:76842245-76842252 (-)	24 bp
Tssr116752	Chr12:76842199-76842238 (-)	54 bp
Tssr116751	Chr12:76842090-76842129 (-)	163 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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