Myo1e MGI Mouse Gene Detail - MGI:106621

Symbol

Myo1e
Name

myosin IE
Synonyms

2310020N23Rik, 9130023P14Rik

Feature Type

protein coding gene
IDs

MGI:106621
NCBI Gene: 71602
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr9:70114632-70307048 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 39.41 cM, cytoband D
Mapping Data

6 experiments

SNPs within 2kb

5703 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106621	protein coding gene	Chr9:70114632-70307349 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034998	protein coding gene	Chr9:70258612-70471841 (+)
A/J	MGP_AJ_G0034979	protein coding gene	Chr9:67831575-68025439 (+)
AKR/J	MGP_AKRJ_G0034908	protein coding gene	Chr9:69433386-69629602 (+)
BALB/cJ	MGP_BALBcJ_G0034971	protein coding gene	Chr9:67552690-67747204 (+)
C3H/HeJ	MGP_C3HHeJ_G0034680	protein coding gene	Chr9:69954304-70159544 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035490	protein coding gene	Chr9:72134939-72342930 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032401	protein coding gene	Chr9:67383956-67579930 (+)
CAST/EiJ	MGP_CASTEiJ_G0034002	protein coding gene	Chr9:70226339-70424335 (+)
CBA/J	MGP_CBAJ_G0034653	protein coding gene	Chr9:74657645-74866274 (+)
DBA/2J	MGP_DBA2J_G0034812	protein coding gene	Chr9:67575836-67769919 (+)
FVB/NJ	MGP_FVBNJ_G0034754	protein coding gene	Chr9:66896395-67090515 (+)
LP/J	MGP_LPJ_G0034893	protein coding gene	Chr9:70497688-70710423 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034795	protein coding gene	Chr9:75740651-75943524 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035512	protein coding gene	Chr9:69588667-69793413 (+)
PWK/PhJ	MGP_PWKPhJ_G0033706	protein coding gene	Chr9:67808091-68011243 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033539	protein coding gene	Chr9:69884955-70088723 (+)
WSB/EiJ	MGP_WSBEiJ_G0034114	protein coding gene	Chr9:69476094-69681731 (+)

Human Ortholog

MYO1E, myosin IE

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO1E, myosin IE
Synonyms

FSGS6, HuncM-IC, MYO1C
Links

HGNC:7599

NCBI Gene ID: 4643

neXtProt AC: NX_Q12965

UniProt: Q12965
Chr Location

15q22.2; chr15:59132434-59372871 (-) GRCh38

MGI Vertebrate Homology

Myo1e stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MYO1E
Gene Tree

Myo1e

Diseases

1 with human MYO1E associations

				Human Disease	Mouse Models
				focal segmental glomerulosclerosis 6 IDs focal segmental glomerulosclerosis 6 DOID:0111131 ICD10CM:N04.1 OMIM:614131

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

33 phenotypes from 3 alleles in 4 genetic backgrounds
6 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

62
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

57
Targeted

2
Genomic Mutations

1 involving Myo1e
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

91 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a gene trapped allele exhibit embryonic lethality, embryonic hemorrhaging and hematopoietic defects. Homozygotes for a knock-out allele show proteinuria, chronic renal injury, kidney inflammation, and defects in renal filtration and podocyte organization.

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All GO Annotations

43
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MYO1E

Xenbase myo1e, myo1e.2

ZFIN myo1ea

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All Sequences

55
RefSeq

4
UniProt

4
CCDS

CCDS40680.1

Ensembl

ENSMUSG00000032220 (Evidence)
NCBI Gene

71602

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032220	Ensembl Gene Model \| MGI Sequence Detail	192417	C57BL/6J	± kb
transcript	ENSMUST00000034745	Ensembl \| MGI Sequence Detail	4625	Not Applicable
polypeptide	ENSMUSP00000034745	Ensembl \| MGI Sequence Detail	1107	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010859 myosin-Ie

(term hierarchy)
PDB

2XMF
InterPro Domains

IPR036072 Class I myosin, motor domain

IPR010926 Class I myosin tail homology domain

IPR050384 Endophilin/SH3RF

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR035507 Unconventional myosin-Ie/If, SH3 domain
GlyGen

E9Q634 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 14

Other 1

Microarray probesets 7

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MGD-MRK-35078, MGI:1913768, MGI:1918852, MGI:2142912

Summaries

All 60

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 19
Earliest

J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
Latest

J:346316 Martinez-Vargas IU, et al., Myo1f has an essential role in gammadeltaT intraepithelial lymphocyte adhesion and migration. Front Immunol. 2023;14:1041079

TSS for Myo1e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85878	Chr9:70114624-70114638 (+)	-1 bp
Tssr85879	Chr9:70114657-70114669 (+)	31 bp
Tssr85880	Chr9:70114680-70114696 (+)	56 bp
Tssr85881	Chr9:70120493-70120496 (+)	5,863 bp
Tssr85882	Chr9:70127997-70128018 (+)	13,376 bp
Tssr85883	Chr9:70128028-70128048 (+)	13,406 bp
Tssr85884	Chr9:70128317-70128326 (+)	13,690 bp
Tssr85885	Chr9:70128356-70128370 (+)	13,731 bp
Tssr85886	Chr9:70142444-70142488 (+)	27,834 bp
Tssr85887	Chr9:70143151-70143183 (+)	28,535 bp
Tssr85888	Chr9:70147649-70147667 (+)	33,026 bp
Tssr85889	Chr9:70157857-70157871 (+)	43,232 bp
Tssr85890	Chr9:70178239-70178242 (+)	63,609 bp
Tssr85891	Chr9:70183171-70183193 (+)	68,550 bp
Tssr85892	Chr9:70188630-70188634 (+)	74,000 bp
Tssr85893	Chr9:70205565-70205574 (+)	90,938 bp
Tssr85895	Chr9:70224465-70224486 (+)	109,844 bp
Tssr85896	Chr9:70228667-70228676 (+)	114,040 bp
Tssr85897	Chr9:70228889-70228933 (+)	114,279 bp
Tssr85899	Chr9:70277688-70277700 (+)	163,062 bp
Tssr2924	Chr9:70297033-70297035 (+)	182,402 bp
Tssr85900	Chr9:70306134-70306153 (+)	191,512 bp
Tssr85901	Chr9:70306605-70306631 (+)	191,986 bp
Tssr85902	Chr9:70306637-70306676 (+)	192,025 bp
Tssr85903	Chr9:70306702-70306713 (+)	192,076 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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