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Srf Gene Detail
Summary
  • Symbol
    Srf
  • Name
    serum response factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:106658
    NCBI Gene: 20807
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46859255-46867101 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106658
 protein coding gene Chr17:46857764-46869194 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023820
 protein coding gene Chr17:47611512-47620719 (-)
A/J MGP_AJ_G0023778
 protein coding gene Chr17:46468883-46478196 (-)
AKR/J MGP_AKRJ_G0023749
 protein coding gene Chr17:46814059-46823380 (-)
BALB/cJ MGP_BALBcJ_G0023782
 protein coding gene Chr17:46371449-46380768 (-)
C3H/HeJ MGP_C3HHeJ_G0023545
 protein coding gene Chr17:47553216-47562531 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024225
 protein coding gene Chr17:49668400-49677713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021675
 protein coding gene Chr17:43255544-43264768 (-)
CAST/EiJ MGP_CASTEiJ_G0023027
 protein coding gene Chr17:47637675-47646894 (-)
CBA/J MGP_CBAJ_G0023522
 protein coding gene Chr17:51447973-51457286 (-)
DBA/2J MGP_DBA2J_G0023648
 protein coding gene Chr17:45248330-45257639 (-)
FVB/NJ MGP_FVBNJ_G0023615
 protein coding gene Chr17:44866085-44875392 (-)
LP/J MGP_LPJ_G0023729
 protein coding gene Chr17:48294240-48303447 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023644
 protein coding gene Chr17:51002569-51011778 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024270
 protein coding gene Chr17:47169157-47178367 (-)
PWK/PhJ MGP_PWKPhJ_G0022772
 protein coding gene Chr17:44587344-44596553 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022587
 protein coding gene Chr17:44044173-44053335 (-)
WSB/EiJ MGP_WSBEiJ_G0023092
 protein coding gene Chr17:47718501-47729085 (-)



Homology
more
  • Human Ortholog
    SRF, serum response factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRF, serum response factor
  • Synonyms
    MCM1
  • Links
    NCBI Gene ID: 6722
    neXtProt AC: NX_P11831
    UniProt: P11831

  • Chr Location
    6p21.1; chr6:43171269-43181506 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Srf mouse models; 2 with human SRF associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    67 phenotypes from 6 alleles in 9 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    123 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit embryonic lethality, abnormal gastrulation, no mesoderm or primitive streak formation and reduced embryo size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    157
  • GO References
    53
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1095
  • Tissues
    274
  • cDNA Data
    78
  • Literature Summary
    67
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015605 Ensembl Gene Model | MGI Sequence Detail 7847 C57BL/6J ±  kb
    transcript ENSMUST00000015749 Ensembl | MGI Sequence Detail 2616 Not Applicable  
    polypeptide ENSMUSP00000015749 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 2
      cDNA 78
      Primer pair 11
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35116, MGI:2147041, MGI:2147058
    References
    more
    • Summaries
      All 274
      Developmental Gene Expression 67
      Diseases 1
      Gene Ontology 53
      Phenotypes 123
    • Earliest
      J:34031 Latinkic BV, et al., Promoter function and structure of the growth factor-inducible immediate early gene cyr61. Nucleic Acids Res. 1991 Jun 25;19(12):3261-7
    • Latest
      J:353778 Iram T, et al., SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination. Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2307250121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory