Sprr1a MGI Mouse Gene Detail - MGI:106660 - small proline-rich protein 1A

Symbol

Sprr1a
Name

small proline-rich protein 1A

Feature Type

protein coding gene
IDs

MGI:106660
NCBI Gene: 20753
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr3:92391261-92393188 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.14 cM
Mapping Data

5 experiments

SNPs within 2kb

122 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106660	protein coding gene	Chr3:92391259-92393202 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027499	protein coding gene	Chr3:92934489-92936432 (-)
A/J	MGP_AJ_G0027466	protein coding gene	Chr3:90008812-90010755 (-)
AKR/J	MGP_AKRJ_G0027431	protein coding gene	Chr3:92115474-92117417 (-)
BALB/cJ	MGP_BALBcJ_G0027474	protein coding gene	Chr3:89820929-89822872 (-)
C3H/HeJ	MGP_C3HHeJ_G0027214	protein coding gene	Chr3:92343503-92345446 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027918	protein coding gene	Chr3:96471671-96473614 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025267	protein coding gene	Chr3:86652796-86654739 (-)
CAST/EiJ	MGP_CASTEiJ_G0026661	protein coding gene	Chr3:91755815-91757758 (-)
CBA/J	MGP_CBAJ_G0027188	protein coding gene	Chr3:99782903-99784846 (-)
DBA/2J	MGP_DBA2J_G0027326	protein coding gene	Chr3:89333177-89335120 (-)
FVB/NJ	MGP_FVBNJ_G0027294	protein coding gene	Chr3:87501312-87503255 (-)
LP/J	MGP_LPJ_G0027434	protein coding gene	Chr3:94148955-94150898 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027318	protein coding gene	Chr3:106030298-106032241 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027977	protein coding gene	Chr3:91848337-91850280 (-)
PWK/PhJ	MGP_PWKPhJ_G0026394	protein coding gene	Chr3:89221103-89223047 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026213	protein coding gene	Chr3:90187409-90189352 (-)
WSB/EiJ	MGP_WSBEiJ_G0026744	protein coding gene	Chr3:92239938-92241881 (-)

Human Ortholog

SPRR1A, small proline rich protein 1A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPRR1A, small proline rich protein 1A
Synonyms

SPRK
Links

HGNC:11259

NCBI Gene ID: 6698

neXtProt AC: NX_P35321

UniProt: P35321
Chr Location

1q21.3; chr1:152984081-152985814 (+) GRCh38

MGI Vertebrate Homology

Sprr1a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPRR1A
Gene Tree

Sprr1a

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Sprr1a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1099
Tissues

280
cDNA Data

29
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS17559.1

Ensembl

ENSMUSG00000050359 (Evidence)
NCBI Gene

20753

			Length	Strain/Species	Flank
genomic	20753	NCBI Gene Model \| MGI Sequence Detail	1928	C57BL/6J	± kb
transcript	NM_009264	RefSeq \| MGI Sequence Detail	807	ZRU/MplStud
polypeptide	Q62266	UniProt \| EBI \| MGI Sequence Detail	144	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015572 cornifin-A

(term hierarchy)
GlyGen

Q62266 1 site, 1 O-linked glycan (1 site)

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All nucleic 34

cDNA 29

Primer pair 4

Other 1

Microarray probesets 2

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MGD-MRK-35118, MGI:2139753

Summaries

All 58

Developmental Gene Expression 20

Diseases 1

Gene Ontology 4

Phenotypes 13
Earliest

J:32027 Kartasova T, et al., Sequence and expression patterns of mouse SPR1: Correlation of expression with epithelial function. J Invest Dermatol. 1996 Feb;106(2):294-304
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sprr1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34296	Chr3:92393193-92393208 (-)	-13 bp
Tssr34295	Chr3:92392004-92392020 (-)	1,176 bp
Tssr34294	Chr3:92391990-92391999 (-)	1,193 bp
Tssr34293	Chr3:92391967-92391978 (-)	1,215 bp
Tssr34292	Chr3:92391924-92391934 (-)	1,259 bp
Tssr34291	Chr3:92391914-92391923 (-)	1,269 bp
Tssr34290	Chr3:92391835-92391847 (-)	1,347 bp
Tssr34289	Chr3:92391791-92391798 (-)	1,393 bp
Tssr34288	Chr3:92391719-92391726 (-)	1,465 bp
Tssr34287	Chr3:92391695-92391701 (-)	1,490 bp
Tssr34286	Chr3:92391667-92391678 (-)	1,515 bp
Tssr34285	Chr3:92391645-92391656 (-)	1,537 bp
Tssr34284	Chr3:92391605-92391637 (-)	1,567 bp
Tssr34283	Chr3:92391513-92391522 (-)	1,670 bp
Tssr34282	Chr3:92391444-92391455 (-)	1,738 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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