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Cd93 Gene Detail
Summary
  • Symbol
    Cd93
  • Name
    CD93 antigen
  • Synonyms
    6030404G09Rik, AA4.1, C1qr1, C1qrp, Ly68
  • Feature Type
    protein coding gene
  • IDs
    MGI:106664
    NCBI Gene: 17064
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:148278571-148285455 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 73.48 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    209 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106664
 protein coding gene Chr2:148278560-148285483 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026608
 protein coding gene Chr2:152779207-152786153 (-)
A/J MGP_AJ_G0026572
 protein coding gene Chr2:146567600-146574635 (-)
AKR/J MGP_AKRJ_G0026546
 protein coding gene Chr2:150798537-150806548 (-)
BALB/cJ MGP_BALBcJ_G0026584
 protein coding gene Chr2:146986217-146993096 (-)
C3H/HeJ MGP_C3HHeJ_G0026327
 protein coding gene Chr2:151294705-151302121 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027029
 protein coding gene Chr2:157220370-157228633 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024407
 protein coding gene Chr2:140570977-140577927 (-)
CAST/EiJ MGP_CASTEiJ_G0025788
 protein coding gene Chr2:151685914-151692391 (-)
CBA/J MGP_CBAJ_G0026307
 protein coding gene Chr2:162991093-162998003 (-)
DBA/2J MGP_DBA2J_G0026441
 protein coding gene Chr2:145839065-145845957 (-)
FVB/NJ MGP_FVBNJ_G0026405
 protein coding gene Chr2:144332354-144339257 (-)
LP/J MGP_LPJ_G0026545
 protein coding gene Chr2:152895111-152902026 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026425
 protein coding gene Chr2:167062921-167069830 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027084
 protein coding gene Chr2:150801385-150808303 (-)
PWK/PhJ MGP_PWKPhJ_G0025524
 protein coding gene Chr2:145515900-145522921 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025325
 protein coding gene Chr2:149774605-149782873 (-)
WSB/EiJ MGP_WSBEiJ_G0025862
 protein coding gene Chr2:151755800-151763221 (-)



Homology
more
  • Human Ortholog
    CD93, CD93 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD93, CD93 molecule
  • Synonyms
    C1QR1, C1qR(P), C1qRP, CDw93, dJ737E23.1, ECSM3, MXRA4
  • Links
    NCBI Gene ID: 22918
    neXtProt AC: NX_Q9NPY3
    UniProt: Q9NPY3

  • Chr Location
    20p11.21; chr20:23079360-23086324 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants have a defect in clearance of apoptotic cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    12
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17064 NCBI Gene Model | MGI Sequence Detail 6885 C57BL/6J ±  kb
transcript NM_010740 RefSeq | MGI Sequence Detail 6638 ZRU/MplStud  
polypeptide O89103 UniProt | EBI | MGI Sequence Detail 644 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000002037 complement component C1q receptor
    (term hierarchy)
  • InterPro Domains
    IPR026823 Complement Clr-like EGF domain
    IPR051505 C-type lectin domain-containing protein
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR049883 NOTCH1 EGF-like calcium-binding domain
  • GlyGen
    O89103 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35123, MGI:1924392, MGI:2139398, MGI:2668130
References
more
  • Summaries
    All 61
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:341949 Lugano R, et al., CD93 maintains endothelial barrier function by limiting the phosphorylation and turnover of VE-cadherin. FASEB J. 2023 Apr;37(4):e22894
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory