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Slc18a2 Gene Detail
Summary
  • Symbol
    Slc18a2
  • Name
    solute carrier family 18 (vesicular monoamine), member 2
  • Synonyms
    1110037L13Rik, Vmat2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106677
    NCBI Gene: 214084
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:59249328-59284444 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 54.64 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    892 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106677
 protein coding gene Chr19:59249310-59284444 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025287
 protein coding gene Chr19:59772608-59808787 (+)
A/J MGP_AJ_G0025263
 protein coding gene Chr19:56855305-56890968 (+)
AKR/J MGP_AKRJ_G0025232
 protein coding gene Chr19:58621995-58657112 (+)
BALB/cJ MGP_BALBcJ_G0025258
 protein coding gene Chr19:56920704-56955817 (+)
C3H/HeJ MGP_C3HHeJ_G0025018
 protein coding gene Chr19:58878617-58913771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025701
 protein coding gene Chr19:61215958-61251018 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023113
 protein coding gene Chr19:55735547-55770850 (+)
CAST/EiJ MGP_CASTEiJ_G0024483
 protein coding gene Chr19:58968882-59004804 (+)
CBA/J MGP_CBAJ_G0024998
 protein coding gene Chr19:64210893-64248902 (+)
DBA/2J MGP_DBA2J_G0025130
 protein coding gene Chr19:56617401-56652824 (+)
FVB/NJ MGP_FVBNJ_G0025091
 protein coding gene Chr19:56345074-56380091 (+)
LP/J MGP_LPJ_G0025216
 protein coding gene Chr19:59647390-59682481 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025124
 protein coding gene Chr19:63422365-63459410 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025759
 protein coding gene Chr19:58868652-58903635 (+)
PWK/PhJ MGP_PWKPhJ_G0024231
 protein coding gene Chr19:56615580-56650840 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024034
 protein coding gene Chr19:57522139-57557252 (+)
WSB/EiJ MGP_WSBEiJ_G0024553
 protein coding gene Chr19:58977080-59012207 (+)



Homology
more
  • Human Ortholog
    SLC18A2, solute carrier family 18 member A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC18A2, solute carrier family 18 member A2
  • Synonyms
    PKDYS2, SVAT, SVMT, VAT2, VMAT2
  • Links
    NCBI Gene ID: 6571
    neXtProt AC: NX_Q05940
    UniProt: Q05940

  • Chr Location
    10q25.3; chr10:117241093-117279430 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SLC18A2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 6 alleles in 7 genetic backgrounds
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit early postnatal death accompanied by reduced body size, hypokinesia, and reduced brain monoamine levels. Hypomorphic mutants show impaired olfaction, gastroparesis, altered sleep latency, neuron degeneration, enhanced MPTP sensitivity, anxiety- and depressive-like behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    123
  • cDNA Data
    16
  • Literature Summary
    56
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025094 Ensembl Gene Model | MGI Sequence Detail 35117 C57BL/6J ±  kb
    transcript ENSMUST00000026084 Ensembl | MGI Sequence Detail 3785 Not Applicable  
    polypeptide ENSMUSP00000026084 Ensembl | MGI Sequence Detail 517 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014967 synaptic vesicular amine transporter
      (term hierarchy)
    • InterPro Domains
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR050930 Major Facilitator Superfamily Vesicular Transporter
      IPR036259 MFS transporter superfamily
      IPR004734 Multidrug resistance protein
    • GlyGen
      Q8BRU6 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 5
      cDNA 18
      Primer pair 6
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35136, MGI:1916004
    References
    more
    • Summaries
      All 159
      Developmental Gene Expression 56
      Gene Ontology 11
      Phenotypes 57
    • Earliest
      J:33165 Roghani A, et al., Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis. Mamm Genome. 1996 May;7(5):393-4
    • Latest
      J:354049 Pulcrano S, et al., miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network. J Neurosci. 2023 Nov 29;43(48):8104-8125
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory