Slc18a1 MGI Mouse Gene Detail - MGI:106684 - solute carrier family 18 (vesicular monoamine), member 1

Symbol

Slc18a1
Name

solute carrier family 18 (vesicular monoamine), member 1
Synonyms

4832416I10Rik, MGC:28683, MGC:37299

Feature Type

protein coding gene
IDs

MGI:106684
NCBI Gene: 110877
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:69490363-69541887 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 33.88 cM
Mapping Data

4 experiments

SNPs within 2kb

1344 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106684	protein coding gene	Chr8:69490360-69547951 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033664	protein coding gene	Chr8:69182268-69236167 (-)
A/J	MGP_AJ_G0033646	protein coding gene	Chr8:66386627-66441384 (-)
AKR/J	MGP_AKRJ_G0033571	protein coding gene	Chr8:68210241-68267844 (-)
BALB/cJ	MGP_BALBcJ_G0033642	protein coding gene	Chr8:66603203-66661204 (-)
C3H/HeJ	MGP_C3HHeJ_G0033352	protein coding gene	Chr8:68931623-68983584 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034159	protein coding gene	Chr8:71791788-71848115 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031106	protein coding gene	Chr8:61266180-61316891 (-)
CAST/EiJ	MGP_CASTEiJ_G0032677	protein coding gene	Chr8:68383585-68436793 (-)
CBA/J	MGP_CBAJ_G0033330	protein coding gene	Chr8:74473522-74525737 (-)
DBA/2J	MGP_DBA2J_G0033484	protein coding gene	Chr8:66103422-66154841 (-)
FVB/NJ	MGP_FVBNJ_G0033425	protein coding gene	Chr8:65258082-65306175 (-)
LP/J	MGP_LPJ_G0033572	protein coding gene	Chr8:69290955-69368808 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033469	protein coding gene	Chr8:77132932-77187958 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034177	protein coding gene	Chr8:68477282-68529241 (-)
PWK/PhJ	MGP_PWKPhJ_G0032386	protein coding gene	Chr8:65351570-65409917 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032222	protein coding gene	Chr8:67448806-67508112 (-)
WSB/EiJ	MGP_WSBEiJ_G0032794	protein coding gene	Chr8:68856146-68910702 (-)

Human Ortholog

SLC18A1, solute carrier family 18 member A1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC18A1, solute carrier family 18 member A1
Synonyms

CGAT, VAT1, VMAT1
Links

HGNC:10934

NCBI Gene ID: 6570

neXtProt AC: NX_P54219

UniProt: P54219
Chr Location

8p21.3; chr8:20144855-20183206 (-) GRCh38

MGI Vertebrate Homology

Slc18a1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLC18A1
Gene Tree

Slc18a1

Diseases

2 with human SLC18A1 associations

				Human Disease	Mouse Models
				bipolar disorder IDs bipolar disorder DOID:3312 DOID:3311 DOID:9554 DOID:9555 ICD10CM:F31 ICD9CM:296.40 ICD9CM:296.60 ICD9CM:296.80 MESH:D001714 NCI:C34423 NCI:C34424 NCI:C34805 UMLS_CUI:C0005586 UMLS_CUI:C0005587 UMLS_CUI:C0024713 UMLS_CUI:C0236780
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

2
Genomic Mutations

1 involving Slc18a1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available

Mice homozygous for a knock-out allele exhibit increased neuron apoptosis, decreased neuron proliferation and impaired spatial object recognition.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

979
Tissues

209
cDNA Data

17
Literature Summary

18

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc18a1

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All Sequences

50
RefSeq

8
UniProt

5
CCDS

CCDS22344.1

Ensembl

ENSMUSG00000036330 (Evidence)
NCBI Gene

110877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036330	Ensembl Gene Model \| MGI Sequence Detail	51525	C57BL/6J	± kb
transcript	ENSMUST00000037478	Ensembl \| MGI Sequence Detail	3115	Not Applicable
polypeptide	ENSMUSP00000046924	Ensembl \| MGI Sequence Detail	521	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014966 chromaffin granule amine transporter

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR050930 Major Facilitator Superfamily Vesicular Transporter

IPR036259 MFS transporter superfamily

IPR004734 Multidrug resistance protein
GlyGen

Q8R090 3 sites

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 3

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MGD-MRK-35143, MGI:2443911

Summaries

All 54

Developmental Gene Expression 18

Gene Ontology 8

Phenotypes 9
Earliest

J:16163 Peter D, et al., Chromosomal localization of the human vesicular amine transporter genes. Genomics. 1993 Dec;18(3):720-3
Latest

J:330805 Sato DX, et al., Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety. iScience. 2022 Aug 19;25(8):104800

TSS for Slc18a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81518	Chr8:69541852-69541867 (-)	27 bp
Tssr81517	Chr8:69537500-69537507 (-)	4,383 bp
Tssr81516	Chr8:69530104-69530115 (-)	11,777 bp
Tssr81515	Chr8:69529904-69529921 (-)	11,974 bp
Tssr81514	Chr8:69529873-69529895 (-)	12,003 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24