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Srpk1 Gene Detail
Summary
  • Symbol
    Srpk1
  • Name
    serine/arginine-rich protein specific kinase 1
  • Synonyms
    SR protein-specific kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106908
    NCBI Gene: 20815
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28806622-28841683 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.78 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106908
 protein coding gene Chr17:28806622-28841795 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023446
 protein coding gene Chr17:28020036-28059435 (-)
A/J MGP_AJ_G0023404
 protein coding gene Chr17:27073094-27111613 (-)
AKR/J MGP_AKRJ_G0023369
 protein coding gene Chr17:27286901-27325493 (-)
BALB/cJ MGP_BALBcJ_G0023409
 protein coding gene Chr17:27357839-27393219 (-)
C3H/HeJ MGP_C3HHeJ_G0023170
 protein coding gene Chr17:27685668-27724168 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023851
 protein coding gene Chr17:29144789-29185316 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021326
 protein coding gene Chr17:24444014-24481741 (-)
CAST/EiJ MGP_CASTEiJ_G0022671
 protein coding gene Chr17:27654284-27688080 (-)
CBA/J MGP_CBAJ_G0023144
 protein coding gene Chr17:30196220-30255849 (-)
DBA/2J MGP_DBA2J_G0023275
 protein coding gene Chr17:26633505-26670857 (-)
FVB/NJ MGP_FVBNJ_G0023245
 protein coding gene Chr17:26456830-26493578 (-)
LP/J MGP_LPJ_G0023353
 protein coding gene Chr17:28270352-28308967 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023263
 protein coding gene Chr17:29598382-29646868 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023893
 protein coding gene Chr17:27727768-27768872 (-)
PWK/PhJ MGP_PWKPhJ_G0022421
 protein coding gene Chr17:25451873-25488075 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022239
 protein coding gene Chr17:25714711-25750949 (-)
WSB/EiJ MGP_WSBEiJ_G0022733
 protein coding gene Chr17:27715065-27754135 (-)



Homology
more
  • Human Ortholog
    SRPK1, SRSF protein kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRPK1, SRSF protein kinase 1
  • Synonyms
    SFRSK1
  • Links
    NCBI Gene ID: 6732
    neXtProt AC: NX_Q96SB4
    UniProt: Q96SB4

  • Chr Location
    6p21.31; chr6:35832966-35921342 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show lethality before E14.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    65
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    95
  • cDNA Data
    21
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004865 Ensembl Gene Model | MGI Sequence Detail 35062 C57BL/6J ±  kb
transcript ENSMUST00000130643 Ensembl | MGI Sequence Detail 4653 Not Applicable  
polypeptide ENSMUSP00000116259 Ensembl | MGI Sequence Detail 648 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-35369, MGI:2146973
References
more
  • Summaries
    All 50
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:33905 Gul JF, et al., A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369(6482):678-682
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory