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Vdac3 Gene Detail
Summary
  • Symbol
    Vdac3
  • Name
    voltage-dependent anion channel 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106922
    NCBI Gene: 22335
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23067102-23083774 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    444 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106922
 protein coding gene Chr8:23067091-23083829 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033454
 protein coding gene Chr8:20429242-20447832 (-)
A/J MGP_AJ_G0033434
 protein coding gene Chr8:19765061-19784160 (-)
AKR/J MGP_AKRJ_G0033359
 protein coding gene Chr8:20416285-20432592 (-)
BALB/cJ MGP_BALBcJ_G0033430
 protein coding gene Chr8:19888478-19906662 (-)
C3H/HeJ MGP_C3HHeJ_G0033144
 protein coding gene Chr8:20612748-20632236 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033946
 protein coding gene Chr8:21290758-21315051 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030899
 protein coding gene Chr8:17095872-17111740 (-)
CAST/EiJ MGP_CASTEiJ_G0032470
 protein coding gene Chr8:20029189-20047250 (-)
CBA/J MGP_CBAJ_G0033119
 protein coding gene Chr8:22141471-22165068 (-)
DBA/2J MGP_DBA2J_G0033274
 protein coding gene Chr8:19732590-19750077 (-)
FVB/NJ MGP_FVBNJ_G0033218
 protein coding gene Chr8:19525634-19548593 (-)
LP/J MGP_LPJ_G0033363
 protein coding gene Chr8:20426082-20443951 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033261
 protein coding gene Chr8:21725364-21762032 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033965
 protein coding gene Chr8:20318763-20337297 (-)
PWK/PhJ MGP_PWKPhJ_G0032182
 protein coding gene Chr8:19320916-19337768 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032015
 protein coding gene Chr8:19705334-19722130 (-)
WSB/EiJ MGP_WSBEiJ_G0032586
 protein coding gene Chr8:20518572-20537739 (-)



Homology
more
  • Human Ortholog
    VDAC3, voltage dependent anion channel 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VDAC3, voltage dependent anion channel 3
  • Synonyms
    HD-VDAC3, VDAC-3
  • Links
    NCBI Gene ID: 7419
    neXtProt AC: NX_Q9Y277
    UniProt: Q9Y277

  • Chr Location
    8p11.21; chr8:42391624-42405937 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    3 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are male sterile with reduced sperm motility and structural defects in the majority of axonemes in epididymal sperm. Mutants of both genders show deficits in behavioral tests measuring contextual or cued fear conditioning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    240
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008892 Ensembl Gene Model | MGI Sequence Detail 16673 C57BL/6J ±  kb
    transcript ENSMUST00000009036 Ensembl | MGI Sequence Detail 1354 Not Applicable  
    polypeptide ENSMUSP00000009036 Ensembl | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000017282 voltage-dependent anion-selective channel protein 3
      (term hierarchy)
    • InterPro Domains
      IPR027246 Eukaryotic porin/Tom40
      IPR023614 Porin domain superfamily
      IPR001925 Porin, eukaryotic type
    • GlyGen
      Q60931 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 243
      Genomic 3
      cDNA 240

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35383
    References
    more
    • Summaries
      All 56
      Gene Ontology 14
      Phenotypes 19
    • Earliest
      J:34931 Sampson MJ, et al., A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8. Genomics. 1996 Aug 15;36(1):192-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory