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Sin3a Gene Detail
Summary
  • Symbol
    Sin3a
  • Name
    transcriptional regulator, SIN3A (yeast)
  • Synonyms
    mSin3A, Sin3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107157
    NCBI Gene: 20466
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:56979324-57035650 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    916 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107157
 protein coding gene Chr9:56979271-57035652 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034858
 protein coding gene Chr9:56241514-56297422 (+)
A/J MGP_AJ_G0034839
 protein coding gene Chr9:54428658-54485400 (+)
AKR/J MGP_AKRJ_G0034768
 protein coding gene Chr9:55684512-55742473 (+)
BALB/cJ MGP_BALBcJ_G0034831
 protein coding gene Chr9:54231106-54287444 (+)
C3H/HeJ MGP_C3HHeJ_G0034541
 protein coding gene Chr9:56157580-56216073 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035350
 protein coding gene Chr9:57827879-57886157 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032261
 protein coding gene Chr9:53766203-53824586 (+)
CAST/EiJ MGP_CASTEiJ_G0033862
 protein coding gene Chr9:56243976-56297834 (+)
CBA/J MGP_CBAJ_G0034512
 protein coding gene Chr9:59841046-59906052 (+)
DBA/2J MGP_DBA2J_G0034671
 protein coding gene Chr9:54309881-54367015 (+)
FVB/NJ MGP_FVBNJ_G0034613
 protein coding gene Chr9:53532137-53589192 (+)
LP/J MGP_LPJ_G0034754
 protein coding gene Chr9:56532503-56591030 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034656
 protein coding gene Chr9:61317356-61376533 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035372
 protein coding gene Chr9:55697969-55758411 (+)
PWK/PhJ MGP_PWKPhJ_G0033567
 protein coding gene Chr9:54340449-54396237 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033401
 protein coding gene Chr9:55995972-56051191 (+)
WSB/EiJ MGP_WSBEiJ_G0033975
 protein coding gene Chr9:55637726-55695861 (+)



Homology
more
  • Human Ortholog
    SIN3A, SIN3 transcription regulator family member A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIN3A, SIN3 transcription regulator family member A
  • Synonyms
    CHR15DELq24, DEL15Q24, WITKOS
  • Links
    NCBI Gene ID: 25942
    neXtProt AC: NX_Q96ST3
    UniProt: Q96ST3

  • Chr Location
    15q24.2; chr15:75369379-75455842 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SIN3A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in early embryonic lethality. Homozygous null MEFs display poor cell proliferation, reduced S-phase and increased G2/M fractions, a block in DNA replication, and enhanced apoptosis; however, no increase in chromosomal instability is observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    119
  • GO References
    55
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    919
  • Tissues
    141
  • cDNA Data
    164
  • Literature Summary
    24
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042557 Ensembl Gene Model | MGI Sequence Detail 56327 C57BL/6J ±  kb
transcript ENSMUST00000168177 Ensembl | MGI Sequence Detail 5086 Not Applicable  
polypeptide ENSMUSP00000130221 Ensembl | MGI Sequence Detail 1277 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 172
    cDNA 165
    Primer pair 6
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-24169, MGD-MRK-35618, MGI:2143326
References
more
  • Summaries
    All 144
    Developmental Gene Expression 24
    Gene Ontology 55
    Phenotypes 26
  • Earliest
    J:28926 Halleck MS, et al., A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3. Genomics. 1995 Mar 20;26(2):403-6
  • Latest
    J:345642 Stokes G, et al., Rescuing lung development through embryonic inhibition of histone acetylation. Sci Transl Med. 2024 Jan 31;16(732):eadc8930
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory