Cst8 MGI Mouse Gene Detail - MGI:107161 - cystatin 8 (cystatin-related epididymal spermatogenic)

Symbol

Cst8
Name

cystatin 8 (cystatin-related epididymal spermatogenic)
Synonyms

Cres, Cst-rs1

Feature Type

protein coding gene
IDs

MGI:107161
NCBI Gene: 13012
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr2:148640759-148647516 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 73.56 cM
Mapping Data

3 experiments

SNPs within 2kb

361 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107161	protein coding gene	Chr2:148640705-148647516 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026616	protein coding gene	Chr2:153147735-153154545 (+)
A/J	MGP_AJ_G0026580	protein coding gene	Chr2:146913948-146920799 (+)
AKR/J	MGP_AKRJ_G0026554	protein coding gene	Chr2:151163277-151170087 (+)
BALB/cJ	MGP_BALBcJ_G0026592	protein coding gene	Chr2:147343394-147350244 (+)
C3H/HeJ	MGP_C3HHeJ_G0026335	protein coding gene	Chr2:151655056-151661906 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027037	protein coding gene	Chr2:157607122-157613932 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024415	protein coding gene	Chr2:140916591-140923519 (+)
CAST/EiJ	MGP_CASTEiJ_G0025796	protein coding gene	Chr2:152052795-152059622 (+)
CBA/J	MGP_CBAJ_G0026315	protein coding gene	Chr2:163383766-163390610 (+)
DBA/2J	MGP_DBA2J_G0026449	protein coding gene	Chr2:146180971-146187811 (+)
FVB/NJ	MGP_FVBNJ_G0026413	protein coding gene	Chr2:144678179-144685013 (+)
LP/J	MGP_LPJ_G0026553	protein coding gene	Chr2:153286143-153292953 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026433	protein coding gene	Chr2:167428080-167434942 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027092	protein coding gene	Chr2:151164075-151170925 (+)
PWK/PhJ	MGP_PWKPhJ_G0025532	protein coding gene	Chr2:145862351-145869262 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025333	protein coding gene	Chr2:150130932-150137770 (+)
WSB/EiJ	MGP_WSBEiJ_G0025870	protein coding gene	Chr2:152113332-152120170 (+)

Human Ortholog

CST8, cystatin 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CST8, cystatin 8
Synonyms

CRES, CTES5
Links

HGNC:2480

NCBI Gene ID: 10047

neXtProt AC: NX_O60676

UniProt: O60676
Chr Location

20p11.21; chr20:23491101-23507124 (+) GRCh38

MGI Vertebrate Homology

Cst8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CST8
Gene Tree

Cst8

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Cst8
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are fertile although males show a small reduction in total and progressive sperm motility, oligozoospermia, and decreased in vitro sperm fertilizing ability associated with impaired sperm capacitation and acrosome reaction.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

16
cDNA Data

23
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

6
UniProt

1
CCDS

CCDS16848.1

Ensembl

ENSMUSG00000027442 (Evidence)
NCBI Gene

13012

			Length	Strain/Species	Flank
genomic	13012	NCBI Gene Model \| MGI Sequence Detail	6758	C57BL/6J	± kb
transcript	NM_009978	RefSeq \| MGI Sequence Detail	703	ZRU/MplStud
polypeptide	P32766	UniProt \| EBI \| MGI Sequence Detail	142	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005970 cystatin-8

(term hierarchy)
PDB

6UIO
InterPro Domains

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily

IPR052691 Sperm Maturation Cystatin
GlyGen

P32766 2 sites, 1 N-linked glycan (1 site)

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All nucleic 30

Genomic 3

cDNA 23

Primer pair 4

Microarray probesets 3

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MGD-MRK-2208, MGD-MRK-35622

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:279308 Fujihara Y, et al., Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18498-18506

TSS for Cst8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20656	Chr2:148640531-148640541 (+)	-223 bp
Tssr20657	Chr2:148640570-148640578 (+)	-185 bp
Tssr20658	Chr2:148640732-148640764 (+)	-11 bp
Tssr20659	Chr2:148640769-148640790 (+)	21 bp
Tssr20660	Chr2:148640792-148640806 (+)	40 bp
Tssr20661	Chr2:148641407-148641418 (+)	654 bp
Tssr20662	Chr2:148641448-148641454 (+)	692 bp
Tssr20663	Chr2:148641474-148641483 (+)	720 bp
Tssr20664	Chr2:148641547-148641574 (+)	802 bp
Tssr20665	Chr2:148641576-148641594 (+)	826 bp
Tssr20666	Chr2:148641624-148641637 (+)	872 bp
Tssr20667	Chr2:148641662-148641676 (+)	910 bp
Tssr20668	Chr2:148641793-148641811 (+)	1,043 bp
Tssr20669	Chr2:148641825-148641830 (+)	1,069 bp
Tssr20670	Chr2:148641869-148641887 (+)	1,119 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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