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Ppp3cb Gene Detail
Summary
  • Symbol
    Ppp3cb
  • Name
    protein phosphatase 3, catalytic subunit, beta isoform
  • Synonyms
    1110063J16Rik, Calnb, Cnab, CnAbeta, PP2BA beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:107163
    NCBI Gene: 19056
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20549432-20596641 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    669 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107163
 protein coding gene Chr14:20549432-20596641 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021038
 protein coding gene Chr14:13260774-13312853 (-)
A/J MGP_AJ_G0020987
 protein coding gene Chr14:12952802-12999852 (-)
AKR/J MGP_AKRJ_G0020964
 protein coding gene Chr14:13478107-13525188 (-)
BALB/cJ MGP_BALBcJ_G0020990
 protein coding gene Chr14:13056725-13103937 (-)
C3H/HeJ MGP_C3HHeJ_G0020774
 protein coding gene Chr14:13415386-13462936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021423
 protein coding gene Chr14:13756881-13808755 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018991
 protein coding gene Chr14:13263487-13313904 (-)
CAST/EiJ MGP_CASTEiJ_G0020298
 protein coding gene Chr14:13176042-13224567 (-)
CBA/J MGP_CBAJ_G0020740
 protein coding gene Chr14:14456616-14508608 (-)
DBA/2J MGP_DBA2J_G0020863
 protein coding gene Chr14:12778570-12825632 (-)
FVB/NJ MGP_FVBNJ_G0020846
 protein coding gene Chr14:12672710-12719654 (-)
LP/J MGP_LPJ_G0020939
 protein coding gene Chr14:13483229-13534309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020872
 protein coding gene Chr14:14227527-14284785 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021456
 protein coding gene Chr14:13265871-13313714 (-)
PWK/PhJ MGP_PWKPhJ_G0020047
 protein coding gene Chr14:12344479-12392501 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019869
 protein coding gene Chr14:13048204-13094712 (-)
WSB/EiJ MGP_WSBEiJ_G0020354
 protein coding gene Chr14:13250074-13299453 (-)



Homology
more
  • Human Ortholog
    PPP3CB, protein phosphatase 3 catalytic subunit beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP3CB, protein phosphatase 3 catalytic subunit beta
  • Synonyms
    CALNA2, CALNB, CNA2, PP2Bbeta
  • Links
    NCBI Gene ID: 5532
    neXtProt AC: NX_P16298
    UniProt: P16298

  • Chr Location
    10q22.2; chr10:73436433-73496024 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPP3CB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 8 alleles in 9 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have small hearts and thymi, and reduced body weight. Cardiac function is normal, but mice lack a cardiac hypertrophic response to pressure overload, angiotensin II, or isopreteronol. Thymi are hypoplastic, with abnormal T cell development and reduced numbers of T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    86
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    37
  • cDNA Data
    17
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19056 NCBI Gene Model | MGI Sequence Detail 47210 C57BL/6J ±  kb
    transcript NM_008914 RefSeq | MGI Sequence Detail 3848 C57BL/6  
    polypeptide P48453 UniProt | EBI | MGI Sequence Detail 525 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013148 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
      (term hierarchy)
    • EC
      3.1.3.16
    • InterPro Domains
      IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
      IPR029052 Metallo-dependent phosphatase-like
      IPR043360 PP2B
      IPR041751 PP2B, metallophosphatase domain
      IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 17
      Primer pair 5
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1737, MGD-MRK-35624, MGI:1913465
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 8
      Gene Ontology 26
      Phenotypes 51
    • Earliest
      J:33287 Guerini D, et al., Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9183-7
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory