Aurkb MGI Mouse Gene Detail - MGI:107168

Symbol

Aurkb
Name

aurora kinase B
Synonyms

Aik2, AIRK2, aurora B, IPL1, STK-1, Stk12, Stk5

Feature Type

protein coding gene
IDs

MGI:107168
NCBI Gene: 20877
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:68936477-68942490 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.32 cM
Mapping Data

4 experiments

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107168	protein coding gene	Chr11:68936473-68942490 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018514	protein coding gene	Chr11:69451272-69457287 (+)
A/J	MGP_AJ_G0018483	protein coding gene	Chr11:66836098-66842115 (+)
AKR/J	MGP_AKRJ_G0018452	protein coding gene	Chr11:68834408-68840601 (+)
BALB/cJ	MGP_BALBcJ_G0018454	protein coding gene	Chr11:67158264-67164281 (+)
C3H/HeJ	MGP_C3HHeJ_G0018267	protein coding gene	Chr11:68855222-68861239 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018906	protein coding gene	Chr11:71560026-71566761 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016550	protein coding gene	Chr11:63776318-63782579 (+)
CAST/EiJ	MGP_CASTEiJ_G0017823	protein coding gene	Chr11:69089762-69095770 (+)
CBA/J	MGP_CBAJ_G0018241	protein coding gene	Chr11:74766022-74772039 (+)
DBA/2J	MGP_DBA2J_G0018350	protein coding gene	Chr11:66436299-66442320 (+)
FVB/NJ	MGP_FVBNJ_G0018340	protein coding gene	Chr11:66055626-66061643 (+)
LP/J	MGP_LPJ_G0018421	protein coding gene	Chr11:70036488-70042503 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018363	protein coding gene	Chr11:75398882-75404899 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018947	protein coding gene	Chr11:69083034-69089057 (+)
PWK/PhJ	MGP_PWKPhJ_G0017598	protein coding gene	Chr11:67070450-67084106 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017386	protein coding gene	Chr11:68915349-68924102 (+)
WSB/EiJ	MGP_WSBEiJ_G0017876	protein coding gene	Chr11:68726191-68732383 (+)

Human Ortholog

AURKB, aurora kinase B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AURKB, aurora kinase B
Synonyms

AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, aurkb-sv1, aurkb-sv2, IPL1, PPP1R48, STK-1, STK12, STK5
Links

HGNC:11390

NCBI Gene ID: 9212

neXtProt AC: NX_Q96GD4

UniProt: Q96GD4
Chr Location

17p13.1; chr17:8204731-8210600 (-) GRCh38

MGI Vertebrate Homology

Aurkb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AURKB
Gene Tree

Aurkb

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Phenotype Summary

28 phenotypes from 5 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

9
Targeted

12
Transgenic

2
Genomic Mutations

1 involving Aurkb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Heterozygous null mice may develop oligospermia and show premature death and increased tumor incidence. Homozygous null embryos are small and die post-implantation showing reduced inner cell mass outgrowth, mitotic defects, aberrant trophoblast giant cells, edema, hemorrhage and increased apoptosis.

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All GO Annotations

111
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

943
Tissues

175
cDNA Data

102
Literature Summary

62

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aurkb

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All Sequences

55
RefSeq

10
UniProt

1
CCDS

CCDS24877.1

Ensembl

ENSMUSG00000020897 (Evidence)
NCBI Gene

20877

			Length	Strain/Species	Flank
genomic	20877	NCBI Gene Model \| MGI Sequence Detail	6014	C57BL/6J	± kb
transcript	NM_001425433	RefSeq \| MGI Sequence Detail	2150	C57BL/6
polypeptide	O70126	UniProt \| EBI \| MGI Sequence Detail	345	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004517 aurora kinase B

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR030616 Aurora kinase-like

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

O70126 1 site, 1 O-linked glycan (1 site)

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All nucleic 112

Genomic 1

cDNA 103

Primer pair 8

Microarray probesets 4

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MGD-MRK-35629, MGI:2141535

Summaries

All 143

Developmental Gene Expression 62

Gene Ontology 19

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354248 Vial Y, et al., Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis. EMBO Rep. 2024 May;25(5):2418-2440

TSS for Aurkb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102364	Chr11:68936466-68936539 (+)	26 bp
Tssr102365	Chr11:68936641-68936648 (+)	168 bp
Tssr102366	Chr11:68936712-68936723 (+)	241 bp
Tssr102367	Chr11:68936725-68936745 (+)	258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24