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Ppp3r1 Gene Detail
Summary
  • Symbol
    Ppp3r1
  • Name
    protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
  • Synonyms
    CaNB1, Cnb1, PP2B beta 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107172
    NCBI Gene: 19058
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:17109298-17150380 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 9.71 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107172
 protein coding gene Chr11:17109263-17150380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018056
 protein coding gene Chr11:14557313-14602189 (+)
A/J MGP_AJ_G0018029
 protein coding gene Chr11:14059896-14101463 (+)
AKR/J MGP_AKRJ_G0017993
 protein coding gene Chr11:14561533-14604145 (+)
BALB/cJ MGP_BALBcJ_G0017997
 protein coding gene Chr11:14173891-14216322 (+)
C3H/HeJ MGP_C3HHeJ_G0017811
 protein coding gene Chr11:14501260-14543898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018449
 protein coding gene Chr11:15182049-15232394 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016107
 protein coding gene Chr11:13228866-13270494 (+)
CAST/EiJ MGP_CASTEiJ_G0017372
 protein coding gene Chr11:14478210-14525106 (+)
CBA/J MGP_CBAJ_G0017785
 protein coding gene Chr11:15988059-16031182 (+)
DBA/2J MGP_DBA2J_G0017895
 protein coding gene Chr11:14043632-14083399 (+)
FVB/NJ MGP_FVBNJ_G0017887
 protein coding gene Chr11:13841072-13885740 (+)
LP/J MGP_LPJ_G0017966
 protein coding gene Chr11:14711921-14754389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017913
 protein coding gene Chr11:16430967-16474215 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018490
 protein coding gene Chr11:14644776-14687280 (+)
PWK/PhJ MGP_PWKPhJ_G0017152
 protein coding gene Chr11:14038790-14081080 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016949
 protein coding gene Chr11:14407505-14452258 (+)
WSB/EiJ MGP_WSBEiJ_G0017426
 protein coding gene Chr11:14345543-14388088 (+)



Homology
more
  • Human Ortholog
    PPP3R1, protein phosphatase 3 regulatory subunit B, alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP3R1, protein phosphatase 3 regulatory subunit B, alpha
  • Synonyms
    CALNB1, CNB, CNB1
  • Links
    NCBI Gene ID: 5534
    neXtProt AC: NX_P63098
    UniProt: P63098

  • Chr Location
    2p14; chr2:68178857-68256237 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ppp3r1 mouse models; 2 with human PPP3R1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 5 alleles in 6 genetic backgrounds
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in embryonic death by midgestation due to vascular patterning defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    20
  • cDNA Data
    130
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19058 NCBI Gene Model | MGI Sequence Detail 41083 C57BL/6J ±  kb
    transcript NM_024459 RefSeq | MGI Sequence Detail 2829 C57BL/6  
    polypeptide Q63810 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      cDNA 130
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35633
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 9
      Diseases 3
      Gene Ontology 23
      Phenotypes 84
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354509 Wu B, et al., PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the Vestibulo-ocular Reflex during Juvenile Development. J Neurosci. 2024 Apr 24;44(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory