Elf1 MGI Mouse Gene Detail - MGI:107180 - E74 like ETS transcription factor 1

Symbol

Elf1
Name

E74 like ETS transcription factor 1
Synonyms

Elf-1

Feature Type

protein coding gene
IDs

MGI:107180
NCBI Gene: 13709
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr14:79718619-79819916 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 42.67 cM
Mapping Data

1 experiment

SNPs within 2kb

2498 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107180	protein coding gene	Chr14:79718619-79819934 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021600	protein coding gene	Chr14:74611082-74714808 (+)
A/J	MGP_AJ_G0021558	protein coding gene	Chr14:72753737-72860854 (+)
AKR/J	MGP_AKRJ_G0021534	protein coding gene	Chr14:74923938-75027246 (+)
BALB/cJ	MGP_BALBcJ_G0021564	protein coding gene	Chr14:72597581-72713055 (+)
C3H/HeJ	MGP_C3HHeJ_G0021342	protein coding gene	Chr14:74651212-74757679 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022004	protein coding gene	Chr14:77776498-77884719 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019543	protein coding gene	Chr14:70294798-70392835 (+)
CAST/EiJ	MGP_CASTEiJ_G0020857	protein coding gene	Chr14:71435748-71541918 (+)
CBA/J	MGP_CBAJ_G0021310	protein coding gene	Chr14:80275652-80394526 (+)
DBA/2J	MGP_DBA2J_G0021434	protein coding gene	Chr14:72155986-72262014 (+)
FVB/NJ	MGP_FVBNJ_G0021410	protein coding gene	Chr14:71497841-71599779 (+)
LP/J	MGP_LPJ_G0021502	protein coding gene	Chr14:75706391-75814153 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021438	protein coding gene	Chr14:78933559-79056217 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022027	protein coding gene	Chr14:74235485-74341850 (+)
PWK/PhJ	MGP_PWKPhJ_G0020602	protein coding gene	Chr14:68949883-69054218 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020438	protein coding gene	Chr14:70209209-70314410 (+)
WSB/EiJ	MGP_WSBEiJ_G0020912	protein coding gene	Chr14:74592758-74700863 (+)

Human Ortholog

ELF1, E74 like ETS transcription factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ELF1, E74 like ETS transcription factor 1
Synonyms

EFTUD1, RIA1
Links

HGNC:3316

NCBI Gene ID: 1997

neXtProt AC: NX_P32519

UniProt: P32519
Chr Location

13q14.11; chr13:40931919-41061440 (-) GRCh38

MGI Vertebrate Homology

Elf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ELF1
Gene Tree

Elf1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

64
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

56
Targeted

4
Genomic Mutations

1 involving Elf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available

Mice homozygous for disruptions in this gene show no obvious phenotypic abnormalities.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1072
Tissues

181
cDNA Data

16
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ELF1

Xenbase elf1

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All Sequences

62
RefSeq

16
UniProt

6
CCDS

CCDS27301.1, CCDS88722.1

Ensembl

ENSMUSG00000036461 (Evidence)
NCBI Gene

13709

			Length	Strain/Species	Flank
genomic	13709	NCBI Gene Model \| MGI Sequence Detail	101298	C57BL/6J	± kb
transcript	NM_007920	RefSeq \| MGI Sequence Detail	4232	C57BL/6
polypeptide	Q60775	UniProt \| EBI \| MGI Sequence Detail	612	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007020 ETS-related transcription factor Elf-1

(term hierarchy)
InterPro Domains

IPR000418 Ets domain

IPR046328 ETS family

IPR022084 Transcription factor Elf, N-terminal

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q60775 1 site, 1 O-linked glycan (1 site)

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All nucleic 21

cDNA 17

Primer pair 3

Other 1

Microarray probesets 5

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MGD-MRK-35641

Summaries

All 70

Developmental Gene Expression 15

Gene Ontology 7

Phenotypes 16
Earliest

J:21040 Gunther CV, et al., Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer. Mol Cell Biol. 1994 Nov;14(11):7569-80
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Elf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126794	Chr14:79718604-79718625 (+)	-4 bp
Tssr126802	Chr14:79768113-79768127 (+)	49,501 bp
Tssr126803	Chr14:79768132-79768147 (+)	49,521 bp
Tssr126804	Chr14:79772975-79773016 (+)	54,377 bp
Tssr126805	Chr14:79773017-79773031 (+)	54,405 bp
Tssr126806	Chr14:79773036-79773047 (+)	54,423 bp
Tssr126807	Chr14:79773080-79773094 (+)	54,468 bp
Tssr126808	Chr14:79773202-79773213 (+)	54,589 bp
Tssr126809	Chr14:79773666-79773676 (+)	55,052 bp
Tssr126810	Chr14:79773776-79773781 (+)	55,160 bp
Tssr126811	Chr14:79777321-79777331 (+)	58,707 bp
Tssr126812	Chr14:79777633-79777644 (+)	59,020 bp
Tssr126813	Chr14:79786836-79786883 (+)	68,241 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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