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Arnt2 Gene Detail
Summary
  • Symbol
    Arnt2
  • Name
    aryl hydrocarbon receptor nuclear translocator 2
  • Synonyms
    bHLHe1, mKIAA0307
  • Feature Type
    protein coding gene
  • IDs
    MGI:107188
    NCBI Gene: 11864
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:83895486-84059201 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.35 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4532 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107188
 protein coding gene Chr7:83895486-84059384 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032458
 protein coding gene Chr7:86426748-86589690 (-)
A/J MGP_AJ_G0032435
 protein coding gene Chr7:84342413-84505318 (-)
AKR/J MGP_AKRJ_G0032372
 protein coding gene Chr7:86294719-86459839 (-)
BALB/cJ MGP_BALBcJ_G0032448
 protein coding gene Chr7:84009736-84171192 (-)
C3H/HeJ MGP_C3HHeJ_G0032162
 protein coding gene Chr7:86841869-87008011 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032939
 protein coding gene Chr7:89766110-89932287 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029947
 protein coding gene Chr7:86689864-86846716 (-)
CAST/EiJ MGP_CASTEiJ_G0031488
 protein coding gene Chr7:77799724-77990212 (-)
CBA/J MGP_CBAJ_G0032127
 protein coding gene Chr7:92784240-92951320 (-)
DBA/2J MGP_DBA2J_G0032282
 protein coding gene Chr7:82845384-83011697 (-)
FVB/NJ MGP_FVBNJ_G0032236
 protein coding gene Chr7:82797259-82958933 (-)
LP/J MGP_LPJ_G0032363
 protein coding gene Chr7:87684209-87849279 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032273
 protein coding gene Chr7:92803928-92987267 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032959
 protein coding gene Chr7:85677256-85842518 (-)
PWK/PhJ MGP_PWKPhJ_G0031209
 protein coding gene Chr7:76062233-76257293 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031051
 protein coding gene Chr7:72622974-72830467 (-)
WSB/EiJ MGP_WSBEiJ_G0031605
 protein coding gene Chr7:86047226-86213685 (-)



Homology
more
  • Human Ortholog
    ARNT2, aryl hydrocarbon receptor nuclear translocator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARNT2, aryl hydrocarbon receptor nuclear translocator 2
  • Synonyms
    bHLHe1, WEDAS
  • Links
    NCBI Gene ID: 9915
    neXtProt AC: NX_Q9HBZ2
    UniProt: Q9HBZ2

  • Chr Location
    15q25.1; chr15:80404350-80597933 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate this gene die shortly after birth, displaying impaired development of secretory neurons in the hypothalamus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1203
  • Tissues
    315
  • cDNA Data
    14
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11864 NCBI Gene Model | MGI Sequence Detail 163716 C57BL/6J ±  kb
    transcript NM_007488 RefSeq | MGI Sequence Detail 6073 ZRU/MplStud  
    polypeptide Q61324 UniProt | EBI | MGI Sequence Detail 712 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 11
      cDNA 15
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-35649
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 24
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:354622 Choi J, et al., ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy. Cell Rep. 2024 Sep 24;43(9):114659
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory