Bmpr1b MGI Mouse Gene Detail - MGI:107191 - bone morphogenetic protein receptor, type 1B

Symbol

Bmpr1b
Name

bone morphogenetic protein receptor, type 1B
Synonyms

Acvrlk6, Alk6, BMPR-IB, CFK-43a

Feature Type

protein coding gene
IDs

MGI:107191
NCBI Gene: 12167
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr3:141542897-141875186 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 66.11 cM
Mapping Data

1 experiment

SNPs within 2kb

10841 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107191	protein coding gene	Chr3:141540230-141875335 (-)
129S1/SvImJ	ENSMUSG00200002213	protein coding gene	Chr3:138327576-138654794 (-)
A/J	ENSMUSG00195003921	protein coding gene	Chr3:138460347-138787584 (-)
AKR/J	ENSMUSG00220003204	protein coding gene	Chr3:136881716-137209286 (-)
BALB/cJ	ENSMUSG00180011191	protein coding gene	Chr3:138349400-138676649 (-)
C3H/HeJ	ENSMUSG00175019480	protein coding gene	Chr3:137953803-138285335 (-)
C57BL/6NJ	ENSMUSG00215014085	protein coding gene	Chr3:138721954-139054258 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025690	protein coding gene	Chr3:135103470-135436920 (-)
CAST/EiJ	ENSTCUG00005028295	protein coding gene	Chr3:139061137-139397753 (-)
CBA/J	ENSMUSG00210029909	protein coding gene	Chr3:138573444-138909124 (-)
DBA/2J	ENSMUSG00185003417	protein coding gene	Chr3:139189850-139520381 (-)
FVB/NJ	ENSMUSG00205014683	protein coding gene	Chr3:137491818-137822416 (-)
JF1/MsJ	ENSUMUG00000003408	protein coding gene	Chr3:137968369-138310926 (-)
LP/J	ENSMUSG00230003086	protein coding gene	Chr3:141140399-141467609 (-)
NOD/ShiLtJ	ENSMUSG00190004143	protein coding gene	Chr3:139575343-139902865 (-)
NZO/HlLtJ	ENSMUSG00225001590	protein coding gene	Chr3:143625585-143953171 (-)
PWK/PhJ	ENSLUMG00010020762	protein coding gene	Chr3:137894114-138236745 (-)
SPRET/EiJ	ENSMSPG00010013632	protein coding gene	Chr3:139133555-139470151 (-)
WSB/EiJ	ENSIUOG00005017855	protein coding gene	Chr3:138721325-139047073 (-)

Human Ortholog

BMPR1B, bone morphogenetic protein receptor type 1B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BMPR1B, bone morphogenetic protein receptor type 1B
Synonyms

ALK-6, ALK6, AMD3, AMDD, BDA1D, BDA2, CDw293
Links

HGNC:1077

NCBI Gene ID: 658

UniProt: O00238
Chr Location

4q22.3; chr4:94757937-95158450 (+) GRCh38

MGI Vertebrate Homology

Bmpr1b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BMPR1B
Gene Tree

Bmpr1b

Diseases

4 with human BMPR1B associations

				Human Disease	Mouse Models
				acromesomelic dysplasia 3 IDs acromesomelic dysplasia 3 DOID:0081237 OMIM:609441
				brachydactyly type A1D IDs brachydactyly type A1D DOID:0110978 OMIM:616849
				brachydactyly type A2 IDs brachydactyly type A2 DOID:0110965 MESH:C537089 OMIM:112600 ORDO:93396 UMLS_CUI:C1832702
				osteochondrodysplasia IDs osteochondrodysplasia DOID:2256 DOID:1764 ICD10CM:Q78.9 ICD9CM:756.4 MESH:D010009 NCI:C34466 NCI:C84978 UMLS_CUI:C0008449 UMLS_CUI:C0029422

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

48 phenotypes from 4 alleles in 5 genetic backgrounds
40 phenotypes from multigenic genotypes
4 images
128 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

7
Gene trapped

1
Radiation induced

1
Targeted

2
Transgenic

3
Transposon induced

1
Genomic Mutations

1 involving Bmpr1b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mutantions of this gene affect the shape of the distal limb skeleton resulting in brachydactyly or failure to generate digit cartilage. Furthermore, inactivation results in female sterility due to abnormal oestrus cyclicity as well as retinal abnormalities.

less

All GO Annotations

100
GO References

31

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1179
Tissues

332
cDNA Data

47
Literature Summary

102

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BMPR1B

Xenbase bmpr1b

ZFIN bmpr1ba, bmpr1bb

less

All Sequences

83
RefSeq

32
UniProt

4
CCDS

CCDS17874.1

Ensembl

ENSMUSG00000052430 (Evidence)
NCBI Gene

12167

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052430	Ensembl Gene Model \| MGI Sequence Detail	332290	C57BL/6J	± kb
transcript	ENSMUST00000106230	Ensembl \| MGI Sequence Detail	2147	Not Applicable
polypeptide	ENSMUSP00000101837	Ensembl \| MGI Sequence Detail	502	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000000036 BMP receptor type-1B

(term hierarchy)
PDB

3EVS
EC

2.7.11.1, 2.7.11.30
InterPro Domains

IPR000472 Activin types I and II receptor domain

IPR003605 GS domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000333 Ser/Thr protein kinase, TGFB receptor

IPR045860 Snake toxin-like superfamily
GlyGen

P36898 1 site, 1 N-linked glycan (1 site)

less

All nucleic 72

cDNA 50

Primer pair 16

Other 6

Antibodies 4

Microarray probesets 6

less

MGD-MRK-35652, MGI:2139685, MGI:2139946

Summaries

All 289

Developmental Gene Expression 102

Diseases 1

Gene Ontology 31

Phenotypes 128
Earliest

J:22224 Yamaji N, et al., A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem Biophys Res Commun. 1994 Dec 30;205(3):1944-51
Latest

J:391206 Peng J, et al., Targeting G(i/o)-coupled GPCRs to inhibit nociceptors: Insights from the serotonin receptor Htr1b and triptans. Cell Rep Med. 2026 Jul 30;:102949

TSS for Bmpr1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35929	Chr3:141875072-141875090 (-)	105 bp
Tssr35928	Chr3:141874957-141875022 (-)	196 bp
Tssr35927	Chr3:141855852-141855858 (-)	19,331 bp
Tssr35926	Chr3:141850518-141850532 (-)	24,661 bp
Tssr35925	Chr3:141814211-141814226 (-)	60,967 bp
Tssr35924	Chr3:141687985-141687998 (-)	187,194 bp
Tssr35923	Chr3:141687967-141687982 (-)	187,211 bp
Tssr35922	Chr3:141637638-141637641 (-)	237,546 bp
Tssr35921	Chr3:141637327-141637337 (-)	237,854 bp
Tssr35920	Chr3:141637315-141637326 (-)	237,865 bp
Tssr35919	Chr3:141637245-141637259 (-)	237,934 bp
Tssr35918	Chr3:141637165-141637200 (-)	238,003 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24