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Gpr143 Gene Detail
Summary
  • Symbol
    Gpr143
  • Name
    G protein-coupled receptor 143
  • Synonyms
    Oa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107193
    NCBI Gene: 18241
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:151564917-151591642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband F2-F3
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    674 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107193
 protein coding gene ChrX:151564917-151591647 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036189
 protein coding gene ChrX:150589153-150621980 (+)
A/J MGP_AJ_G0036165
 protein coding gene ChrX:149774427-149801207 (+)
AKR/J MGP_AKRJ_G0036091
 protein coding gene ChrX:154581598-154610392 (+)
BALB/cJ MGP_BALBcJ_G0036156
 protein coding gene ChrX:147939628-147965819 (+)
C3H/HeJ MGP_C3HHeJ_G0035864
 protein coding gene ChrX:150796590-150827012 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036681
 protein coding gene ChrX:154901157-154932803 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033505
 protein coding gene ChrX:141452730-141478867 (+)
CAST/EiJ MGP_CASTEiJ_G0035155
 protein coding gene ChrX:130173452-130202477 (+)
CBA/J MGP_CBAJ_G0035841
 protein coding gene ChrX:159413480-159438664 (+)
DBA/2J MGP_DBA2J_G0035999
 protein coding gene ChrX:148791905-148818878 (+)
FVB/NJ MGP_FVBNJ_G0035933
 protein coding gene ChrX:147950357-147979564 (+)
LP/J MGP_LPJ_G0036090
 protein coding gene ChrX:151642899-151675983 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035969
 protein coding gene ChrX:167623467-167651590 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036716
 protein coding gene ChrX:150105447-150136479 (+)
PWK/PhJ MGP_PWKPhJ_G0034849
 protein coding gene ChrX:127096062-127124052 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034675
 protein coding gene ChrX:130604174-130636101 (+)
WSB/EiJ MGP_WSBEiJ_G0035290
 protein coding gene ChrX:148144340-148172166 (+)



Homology
more
  • Human Ortholog
    GPR143, G protein-coupled receptor 143
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR143, G protein-coupled receptor 143
  • Synonyms
    NYS6, OA1
  • Links
    NCBI Gene ID: 4935
    neXtProt AC: NX_P51810
    UniProt: P51810

  • Chr Location
    Xp22.2; chrX:9725346-9786297 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gpr143 mouse models; 2 with human GPR143 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous males exhibit hypopigmentation of the ocular fundus, misrouting of the optic fibers at the chiasm, and the presence of giant melanosomes in the pigment epithelium of the eye.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    29
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025333 Ensembl Gene Model | MGI Sequence Detail 26726 C57BL/6J ±  kb
    transcript ENSMUST00000026383 Ensembl | MGI Sequence Detail 1586 Not Applicable  
    polypeptide ENSMUSP00000026383 Ensembl | MGI Sequence Detail 405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 6
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35654
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:33821 Dinulos MB, et al., A new region of conservation is defined between human and mouse X chromosomes. Genomics. 1996 Jul 1;35(1):244-7
    • Latest
      J:347253 Arai M, et al., Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons. J Neurosci. 2024 Mar 13;44(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory