Cpd MGI Mouse Gene Detail - MGI:107265

Symbol

Cpd
Name

carboxypeptidase D
Synonyms

D830034L15Rik

Feature Type

protein coding gene
IDs

MGI:107265
NCBI Gene: 12874
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:76669250-76737844 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.05 cM
Mapping Data

4 experiments

SNPs within 2kb

1454 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107265	protein coding gene	Chr11:76668034-76737844 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018739	protein coding gene	Chr11:77635837-77700299 (-)
A/J	MGP_AJ_G0018705	protein coding gene	Chr11:74723610-74789559 (-)
AKR/J	MGP_AKRJ_G0018675	protein coding gene	Chr11:76986457-77049261 (-)
BALB/cJ	MGP_BALBcJ_G0018679	protein coding gene	Chr11:75103918-75166517 (-)
C3H/HeJ	MGP_C3HHeJ_G0018492	protein coding gene	Chr11:77012212-77076508 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019130	protein coding gene	Chr11:80081153-80148890 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016765	protein coding gene	Chr11:71713520-71783415 (-)
CAST/EiJ	MGP_CASTEiJ_G0018046	protein coding gene	Chr11:77407754-77472552 (-)
CBA/J	MGP_CBAJ_G0018462	protein coding gene	Chr11:83575824-83640184 (-)
DBA/2J	MGP_DBA2J_G0018571	protein coding gene	Chr11:74315880-74379368 (-)
FVB/NJ	MGP_FVBNJ_G0018561	protein coding gene	Chr11:73873476-73935916 (-)
LP/J	MGP_LPJ_G0018642	protein coding gene	Chr11:78222844-78320062 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018587	protein coding gene	Chr11:84037390-84104513 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019170	protein coding gene	Chr11:77188195-77257076 (-)
PWK/PhJ	MGP_PWKPhJ_G0017817	protein coding gene	Chr11:75052746-75118934 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017608	protein coding gene	Chr11:76764579-76837502 (-)
WSB/EiJ	MGP_WSBEiJ_G0018099	protein coding gene	Chr11:77019927-77084372 (-)

Human Ortholog

CPD, carboxypeptidase D

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPD, carboxypeptidase D
Synonyms

GP180
Links

HGNC:2301

NCBI Gene ID: 1362

neXtProt AC: NX_O75976

UniProt: O75976
Chr Location

17q11.2; chr17:30378927-30469989 (+) GRCh38

MGI Vertebrate Homology

Cpd stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CPD
Gene Tree

Cpd

less

Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

1
Genomic Mutations

2 involving Cpd
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

107
cDNA Data

23
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cpd

less

All Sequences

48
RefSeq

2
UniProt

1
CCDS

CCDS25071.1

Ensembl

ENSMUSG00000020841 (Evidence)
NCBI Gene

12874

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020841	Ensembl Gene Model \| MGI Sequence Detail	68595	C57BL/6J	± kb
transcript	ENSMUST00000021201	Ensembl \| MGI Sequence Detail	7946	Not Applicable
polypeptide	ENSMUSP00000021201	Ensembl \| MGI Sequence Detail	1377	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000005803 carboxypeptidase D

(term hierarchy)
EC

3.4.17.22
InterPro Domains

IPR034224 Carboxypeptidase D, carboxypeptidase-like domain 2

IPR033848 Carboxypeptidase D, carboxypeptidase-like domain 3

IPR008969 Carboxypeptidase-like, regulatory domain superfamily

IPR000834 Peptidase M14, carboxypeptidase A

IPR050753 Peptidase M14 domain-containing protein
GlyGen

O89001 16 sites, 15 N-linked glycans (11 sites), 1 O-linked glycan (1 site)

less

All nucleic 28

cDNA 25

Primer pair 3

Microarray probesets 13

less

MGD-MRK-35730, MGI:2144054, MGI:2144525

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cpd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109317	Chr11:76737873-76737878 (-)	-32 bp
Tssr109316	Chr11:76737794-76737871 (-)	11 bp
Tssr109315	Chr11:76735143-76735146 (-)	2,699 bp
Tssr109314	Chr11:76703268-76703280 (-)	34,570 bp
Tssr109313	Chr11:76699866-76699870 (-)	37,976 bp
Tssr109312	Chr11:76678428-76678443 (-)	59,408 bp
Tssr109311	Chr11:76670050-76670069 (-)	67,784 bp
Tssr109310	Chr11:76669814-76669834 (-)	68,020 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24