Cux2 MGI Mouse Gene Detail - MGI:107321

Symbol

Cux2
Name

cut-like homeobox 2
Synonyms

1700051K22Rik, Cutl2, Cux-2, Cux2, ENSMUSG00000072641

Feature Type

protein coding gene
IDs

MGI:107321
NCBI Gene: 13048
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr5:121996025-122188522 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.02 cM
Mapping Data

4 experiments

SNPs within 2kb

5420 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107321	protein coding gene	Chr5:121994429-122188522 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030040	protein coding gene	Chr5:125433292-125647049 (-)
A/J	MGP_AJ_G0030005	protein coding gene	Chr5:120273947-120463872 (-)
AKR/J	MGP_AKRJ_G0029941	protein coding gene	Chr5:124140178-124332757 (-)
BALB/cJ	MGP_BALBcJ_G0030016	protein coding gene	Chr5:121611613-121807110 (-)
C3H/HeJ	MGP_C3HHeJ_G0029733	protein coding gene	Chr5:124720713-124934503 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030469	protein coding gene	Chr5:130215887-130470171 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027695	protein coding gene	Chr5:114890457-115079662 (-)
CAST/EiJ	MGP_CASTEiJ_G0029142	protein coding gene	Chr5:123820565-124038234 (-)
CBA/J	MGP_CBAJ_G0029703	protein coding gene	Chr5:135335345-135581353 (-)
DBA/2J	MGP_DBA2J_G0029853	protein coding gene	Chr5:120324036-120516615 (-)
FVB/NJ	MGP_FVBNJ_G0029809	protein coding gene	Chr5:119289570-119492987 (-)
LP/J	MGP_LPJ_G0029942	protein coding gene	Chr5:125977197-126188814 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029840	protein coding gene	Chr5:139151663-139375150 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030510	protein coding gene	Chr5:123690904-123902394 (-)
PWK/PhJ	MGP_PWKPhJ_G0028856	protein coding gene	Chr5:119071682-119271052 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028693	protein coding gene	Chr5:121413665-121617737 (-)
WSB/EiJ	MGP_WSBEiJ_G0029217	protein coding gene	Chr5:124362885-124583865 (-)

Human Ortholog

CUX2, cut like homeobox 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CUX2, cut like homeobox 2
Synonyms

CDP2, CUTL2, DEE67, EIEE67
Links

HGNC:19347

NCBI Gene ID: 23316

neXtProt AC: NX_O14529

UniProt: O14529
Chr Location

12q24.11-q24.12; chr12:111034165-111350554 (+) GRCh38

MGI Vertebrate Homology

Cux2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CUX2
Gene Tree

Cux2

Diseases

1 with human CUX2 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 67 IDs developmental and epileptic encephalopathy 67 DOID:0112203 OMIM:618141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotypes from multigenic genotypes
78 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

11
Radiation induced

1
Targeted

8
Genomic Mutations

2 involving Cux2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a targeted null mutation exhibit various neural defects.

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All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1134
Tissues

193
cDNA Data

15
Literature Summary

113

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cux2

ZFIN cux2a, cux2b

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All Sequences

92
RefSeq

42
UniProt

5
CCDS

CCDS39251.1

Ensembl

ENSMUSG00000042589 (Evidence)
NCBI Gene

13048

			Length	Strain/Species	Flank
genomic	13048	NCBI Gene Model \| MGI Sequence Detail	192498	C57BL/6J	± kb
transcript	NM_007804	RefSeq \| MGI Sequence Detail	7405	C57BL/6
polypeptide	P70298	UniProt \| EBI \| MGI Sequence Detail	1426	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006056 homeobox protein cut-like 2

(term hierarchy)
InterPro Domains

IPR003350 CUT domain

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR010982 Lambda repressor-like, DNA-binding domain superfamily

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All nucleic 28

Genomic 1

cDNA 16

Primer pair 4

Other 7

Microarray probesets 8

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MGD-MRK-35787, MGI:1920667, MGI:3710627

Summaries

All 212

Developmental Gene Expression 113

Gene Ontology 5

Phenotypes 78
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354227 Barao S, et al., Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Nat Commun. 2024 Sep 14;15(1):8043

TSS for Cux2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53073	Chr5:122188281-122188294 (-)	234 bp
Tssr53072	Chr5:122188196-122188221 (-)	313 bp
Tssr53071	Chr5:122187885-122187945 (-)	607 bp
Tssr53070	Chr5:122157458-122157492 (-)	31,047 bp
Tssr53069	Chr5:122140403-122140431 (-)	48,105 bp
Tssr53068	Chr5:122140374-122140383 (-)	48,143 bp
Tssr53067	Chr5:122054783-122054820 (-)	133,720 bp
Tssr53066	Chr5:122033407-122033412 (-)	155,112 bp
Tssr53065	Chr5:121998166-121998169 (-)	190,354 bp
Tssr53064	Chr5:121998043-121998047 (-)	190,477 bp
Tssr53063	Chr5:121997210-121997213 (-)	191,310 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24