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Ube2i Gene Detail
Summary
  • Symbol
    Ube2i
  • Name
    ubiquitin-conjugating enzyme E2I
  • Synonyms
    5830467E05Rik, Mmubc9, UBC9, Ubce9
  • Feature Type
    protein coding gene
  • IDs
    MGI:107365
    NCBI Gene: 22196
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25479482-25493856 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    337 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107365
 protein coding gene Chr17:25479482-25494965 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023348
 protein coding gene Chr17:24312827-24328492 (-)
A/J MGP_AJ_G0023307
 protein coding gene Chr17:23633732-23647407 (-)
AKR/J MGP_AKRJ_G0023273
 protein coding gene Chr17:23723740-23738684 (-)
BALB/cJ MGP_BALBcJ_G0023312
 protein coding gene Chr17:23831763-23846847 (-)
C3H/HeJ MGP_C3HHeJ_G0023072
 protein coding gene Chr17:24103097-24117582 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023754
 protein coding gene Chr17:25379764-25390030 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021230
 protein coding gene Chr17:21094873-21108034 (-)
CAST/EiJ MGP_CASTEiJ_G0022574
 protein coding gene Chr17:23952600-23965387 (-)
CBA/J MGP_CBAJ_G0023047
 protein coding gene Chr17:26241204-26254507 (-)
DBA/2J MGP_DBA2J_G0023177
 protein coding gene Chr17:23218566-23231479 (-)
FVB/NJ MGP_FVBNJ_G0023147
 protein coding gene Chr17:22948098-22961432 (-)
LP/J MGP_LPJ_G0023254
 protein coding gene Chr17:24605587-24620902 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023166
 protein coding gene Chr17:25901193-25914515 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023794
 protein coding gene Chr17:24010044-24025223 (-)
PWK/PhJ MGP_PWKPhJ_G0022323
 protein coding gene Chr17:21983399-21995548 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022141
 protein coding gene Chr17:22097107-22113026 (-)
WSB/EiJ MGP_WSBEiJ_G0022637
 protein coding gene Chr17:24084807-24097772 (-)



Homology
more
  • Human Ortholog
    UBE2I, ubiquitin conjugating enzyme E2 I
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE2I, ubiquitin conjugating enzyme E2 I
  • Synonyms
    C358B7.1, P18, UBC9
  • Links
    NCBI Gene ID: 7329
    neXtProt AC: NX_P63279
    UniProt: P63279

  • Chr Location
    16p13.3; chr16:1291444-1327018 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation die prior to E7.5. In culture, mutant blastocysts are viable up to 2 days but show subsequent apoptosis of the inner cell mass. Mutant cells exhibit major chromosome condensation and segregation defects as well as gross defects in nuclear organization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    21
  • cDNA Data
    38
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015120 Ensembl Gene Model | MGI Sequence Detail 14375 C57BL/6J ±  kb
    transcript ENSMUST00000249697 Ensembl | MGI Sequence Detail 1080 Not Applicable  
    polypeptide ENSMUSP00000159871 Ensembl | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 1
      cDNA 38
      Other 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGD-MRK-35832, MGI:1923335
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 9
      Gene Ontology 25
      Phenotypes 32
    • Earliest
      J:32204 Kovalenko OV, et al., Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2958-63
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory