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Gstt1 Gene Detail
Summary
  • Symbol
    Gstt1
  • Name
    glutathione S-transferase, theta 1
  • Synonyms
    Gstt1-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107379
    NCBI Gene: 14871
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75619647-75634418 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.58 cM, cytoband B5-C1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    458 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107379
 protein coding gene Chr10:75619647-75634418 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017365
 protein coding gene Chr10:75969411-75987177 (-)
A/J MGP_AJ_G0017342
 protein coding gene Chr10:73362933-73377593 (-)
AKR/J MGP_AKRJ_G0017303
 protein coding gene Chr10:75327747-75343978 (-)
BALB/cJ MGP_BALBcJ_G0017302
 protein coding gene Chr10:73558657-73573266 (-)
C3H/HeJ MGP_C3HHeJ_G0017126
 protein coding gene Chr10:75366852-75383624 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017760
 protein coding gene Chr10:78657014-78673090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015450
 protein coding gene Chr10:69817238-69831510 (-)
CAST/EiJ MGP_CASTEiJ_G0016697
 protein coding gene Chr10:75687494-75704510 (-)
CBA/J MGP_CBAJ_G0017098
 protein coding gene Chr10:81725153-81742548 (-)
DBA/2J MGP_DBA2J_G0017203
 protein coding gene Chr10:72664629-72679649 (-)
FVB/NJ MGP_FVBNJ_G0017196
 protein coding gene Chr10:71813090-71830171 (-)
LP/J MGP_LPJ_G0017276
 protein coding gene Chr10:76475386-76491710 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017224
 protein coding gene Chr10:83818525-83835564 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017799
 protein coding gene Chr10:75360771-75376610 (-)
PWK/PhJ MGP_PWKPhJ_G0016480
 protein coding gene Chr10:72490578-72505500 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016263
 protein coding gene Chr10:74600995-74621761 (-)
WSB/EiJ MGP_WSBEiJ_G0016760
 protein coding gene Chr10:75333192-75362261 (-)



Homology
more
  • Human Ortholog
    GSTT1, glutathione S-transferase theta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTT1, glutathione S-transferase theta 1
  • Links
    NCBI Gene ID: 2952
    neXtProt AC: NX_P30711
    UniProt: P30711

  • Chr Location
    22q11.23
Human Diseases
more
  • Diseases
    86 with human GSTT1 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mis homozygous for disruption of this gene appear to be normal and fertile with the exception of a reduced ability to clear 11,2-bis(2-chloroethyl)-1-nitrosourea from the plasma after a single i.p. dose.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    96
  • cDNA Data
    67
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14871 NCBI Gene Model | MGI Sequence Detail 14772 C57BL/6J ±  kb
    transcript NM_008185 RefSeq | MGI Sequence Detail 1049 ZRU/MplStud  
    polypeptide Q64471 UniProt | EBI | MGI Sequence Detail 240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
      2.5.1.18
    • InterPro Domains
      IPR004046 Glutathione S-transferase, C-terminal
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR010987 Glutathione S-transferase, C-terminal-like
      IPR004045 Glutathione S-transferase, N-terminal
      IPR051369 Glutathione S-transferase Theta
      IPR040077 Glutathione S-transferase Theta, C-terminal
      IPR040075 Glutathione S-transferase Theta, N-terminal
      IPR040079 Glutathione transferase family
      IPR036249 Thioredoxin-like superfamily
    • GlyGen
      Q64471 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 86
      Genomic 16
      cDNA 67
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35846, MGI:2143546
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory