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Lefty1 Gene Detail
Summary
  • Symbol
    Lefty1
  • Name
    left right determination factor 1
  • Synonyms
    Ebaf, Lefty, lefty-1, Stra3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107405
    NCBI Gene: 13590
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:180762587-180765965 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.46 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107405
 protein coding gene Chr1:180762587-180765966 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016878
 protein coding gene Chr1:187414947-187420197 (+)
A/J MGP_AJ_G0016857
 protein coding gene Chr1:179823989-179828431 (+)
AKR/J MGP_AKRJ_G0016823
 protein coding gene Chr1:185170491-185173932 (+)
BALB/cJ MGP_BALBcJ_G0016815
 protein coding gene Chr1:180447472-180451809 (+)
C3H/HeJ MGP_C3HHeJ_G0016640
 protein coding gene Chr1:185947059-185950417 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017277
 protein coding gene Chr1:193416666-193434366 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014985
 protein coding gene Chr1:170760719-170764671 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0016614
 protein coding gene Chr1:200637716-200641090 (+)
DBA/2J MGP_DBA2J_G0016720
 protein coding gene Chr1:178660842-178664390 (+)
FVB/NJ MGP_FVBNJ_G0016716
 protein coding gene Chr1:176760591-176763945 (+)
LP/J MGP_LPJ_G0016794
 protein coding gene Chr1:188668211-188672312 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016747
 protein coding gene Chr1:207801809-207807647 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017315
 protein coding gene Chr1:184948850-184952291 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0015784
 protein coding gene Chr1:183844352-183848194 (+)
WSB/EiJ MGP_WSBEiJ_G0016284
 protein coding gene Chr1:185152059-185155824 (+)



Homology
more
  • Human Ortholog
    LEFTY1, left-right determination factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LEFTY1, left-right determination factor 1
  • Synonyms
    LEFTB, LEFTYB
  • Links
    NCBI Gene ID: 10637
    neXtProt AC: NX_O75610
    UniProt: O75610

  • Chr Location
    1q42.12; chr1:225886282-225911382 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    23 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show embryonic and postnatal lethality, abnormal liver lobation, and a variety of left-right positional defects in visceral organs including left thoracic and atrial isomerism. A subset of mice homozygous for a differentnull allele show left pulmonary isomerism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1079
  • Tissues
    88
  • cDNA Data
    27
  • Literature Summary
    157
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038793 Ensembl Gene Model | MGI Sequence Detail 3379 C57BL/6J ±  kb
    transcript ENSMUST00000037361 Ensembl | MGI Sequence Detail 1620 Not Applicable  
    polypeptide ENSMUSP00000041427 Ensembl | MGI Sequence Detail 368 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR003942 Left- Right determination factor
      IPR001111 TGF-beta, propeptide
      IPR017948 Transforming growth factor beta, conserved site
      IPR001839 Transforming growth factor-beta, C-terminal
      IPR015615 Transforming growth factor-beta-related
    • GlyGen
      Q64280 1 site
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 7
      cDNA 32
      Primer pair 7
      Other 25

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35873, MGD-MRK-36501, MGI:107921, MGI:2138250
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 157
      Gene Ontology 8
      Phenotypes 30
    • Earliest
      J:31593 Cereghini S, et al., Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development. 1992 Nov;116(3):783-97
    • Latest
      J:354455 Chen X, et al., SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development. Int J Biol Macromol. 2024 Aug;274(Pt 2):133294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory