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Gdnf Gene Detail
Summary
  • Symbol
    Gdnf
  • Name
    glial cell line derived neurotrophic factor
  • Synonyms
    glial cell line-derived neurotrophic factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:107430
    NCBI Gene: 14573
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:7840327-7867056 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    685 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107430
 protein coding gene Chr15:7839529-7867061 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021702
 protein coding gene Chr15:4837559-4870944 (+)
A/J MGP_AJ_G0021663
 protein coding gene Chr15:4728671-4753652 (+)
AKR/J MGP_AKRJ_G0021641
 protein coding gene Chr15:4761088-4787128 (+)
BALB/cJ MGP_BALBcJ_G0021670
 protein coding gene Chr15:4630886-4658093 (+)
C3H/HeJ MGP_C3HHeJ_G0021446
 protein coding gene Chr15:4794085-4820642 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022109
 protein coding gene Chr15:5019189-5043229 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019646
 protein coding gene Chr15:4330030-4354500 (+)
CAST/EiJ MGP_CASTEiJ_G0020962
 protein coding gene Chr15:4782757-4815815 (+)
CBA/J MGP_CBAJ_G0021415
 protein coding gene Chr15:5120416-5148962 (+)
DBA/2J MGP_DBA2J_G0021539
 protein coding gene Chr15:4652655-4681746 (+)
FVB/NJ MGP_FVBNJ_G0021517
 protein coding gene Chr15:4571274-4595481 (+)
LP/J MGP_LPJ_G0021607
 protein coding gene Chr15:4761556-4791631 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021542
 protein coding gene Chr15:5291416-5317142 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022132
 protein coding gene Chr15:4802267-4826416 (+)
PWK/PhJ MGP_PWKPhJ_G0020705
 protein coding gene Chr15:4663716-4689880 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020543
 protein coding gene Chr15:4692538-4716883 (+)
WSB/EiJ MGP_WSBEiJ_G0021018
 protein coding gene Chr15:4725233-4751961 (+)



Homology
more
  • Human Ortholog
    GDNF, glial cell derived neurotrophic factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDNF, glial cell derived neurotrophic factor
  • Synonyms
    ATF, ATF1, ATF2, HFB1-GDNF, HSCR3
  • Links
    NCBI Gene ID: 2668
    neXtProt AC: NX_P39905
    UniProt: P39905

  • Chr Location
    5p13.2; chr5:37812677-37840041 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gdnf mouse models; 7 with human GDNF associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 7 alleles in 12 genetic backgrounds
    12 phenotypes from multigenic genotypes
    123 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to lack of ureteric bud induction, bilateral renal agenesis, absence of enteric neurons, and neonatal death. Heterozygotes show renal phenotypes ranging from two small kidneys, often with abnormal shapes and cortical cysts, to unilateral renal agenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1254
  • Tissues
    253
  • cDNA Data
    16
  • Literature Summary
    225
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022144 Ensembl Gene Model | MGI Sequence Detail 26730 C57BL/6J ±  kb
    transcript ENSMUST00000022744 Ensembl | MGI Sequence Detail 3674 Not Applicable  
    polypeptide ENSMUSP00000022744 Ensembl | MGI Sequence Detail 240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007928 glial cell line-derived neurotrophic factor
      (term hierarchy)
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR016649 Glial cell line-derived neurotrophic factor
      IPR043401 Glial cell line-derived neurotrophic factor family
      IPR047020 Glial cell line-derived neurotrophic factor, TGF-beta-like domain
      IPR001839 Transforming growth factor-beta, C-terminal
    • GlyGen
      P48540 2 sites
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 4
      cDNA 22
      Primer pair 25
      Other 25

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35901, MGI:2145987
    References
    more
    • Summaries
      All 414
      Developmental Gene Expression 225
      Diseases 3
      Gene Ontology 26
      Phenotypes 123
    • Earliest
      J:38540 Lin LF, et al., GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons [see comments]. Science. 1993 May 21;260(5111):1130-2
    • Latest
      J:350416 Montano-Rodriguez AR, et al., Striatal GDNF Neurons Chemoattract RET-Positive Dopamine Axons at Seven Times Farther Distance Than Medium Spiny Neurons. Cells. 2024 Jun 19;13(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory