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Cdh8 Gene Detail
Summary
  • Symbol
    Cdh8
  • Name
    cadherin 8
  • Synonyms
    cad8
  • Feature Type
    protein coding gene
  • IDs
    MGI:107434
    NCBI Gene: 12564
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:99751103-100143103 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 49.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12503 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107434
 protein coding gene Chr8:99751103-100144298 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033996
 protein coding gene Chr8:100693094-101102137 (-)
A/J MGP_AJ_G0033979
 protein coding gene Chr8:96747163-97150328 (-)
AKR/J MGP_AKRJ_G0033905
 protein coding gene Chr8:99403793-99818311 (-)
BALB/cJ MGP_BALBcJ_G0033971
 protein coding gene Chr8:96846405-97238477 (-)
C3H/HeJ MGP_C3HHeJ_G0033681
 protein coding gene Chr8:100190117-100596148 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034492
 protein coding gene Chr8:104373361-104790845 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031434
 protein coding gene Chr8:90479290-90869036 (-)
CAST/EiJ MGP_CASTEiJ_G0033013
 protein coding gene Chr8:99692431-100122112 (-)
CBA/J MGP_CBAJ_G0033657
 protein coding gene Chr8:107902617-108345571 (-)
DBA/2J MGP_DBA2J_G0033811
 protein coding gene Chr8:96206960-96602794 (-)
FVB/NJ MGP_FVBNJ_G0033758
 protein coding gene Chr8:95115393-95509451 (-)
LP/J MGP_LPJ_G0033903
 protein coding gene Chr8:100802026-101218922 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033800
 protein coding gene Chr8:110410571-110919967 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034510
 protein coding gene Chr8:99581972-99978745 (-)
PWK/PhJ MGP_PWKPhJ_G0032715
 protein coding gene Chr8:95620318-96023609 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032552
 protein coding gene Chr8:98415399-98834281 (-)
WSB/EiJ MGP_WSBEiJ_G0033125
 protein coding gene Chr8:100081610-100494463 (-)



Homology
more
  • Human Ortholog
    CDH8, cadherin 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH8, cadherin 8
  • Synonyms
    Nbla04261
  • Links
    NCBI Gene ID: 1006
    neXtProt AC: NX_P55286
    UniProt: P55286

  • Chr Location
    16q21; chr16:61647242-62037035 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile and overtly normal but display abnormal CNS synaptic transmission, raise their tails in response to stress, and show reduced sensitivity to cutaneous cold stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1478
  • Tissues
    359
  • cDNA Data
    28
  • Literature Summary
    107
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036510 Ensembl Gene Model | MGI Sequence Detail 392001 C57BL/6J ±  kb
    transcript ENSMUST00000128860 Ensembl | MGI Sequence Detail 4594 Not Applicable  
    polypeptide ENSMUSP00000117326 Ensembl | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 37
      Primer pair 8
      Other 11

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35905, MGI:2142634
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 107
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:32957 Munro SB, et al., Characterization of cadherins expressed by murine thymocytes. Cell Immunol. 1996 May 1;169(2):309-12
    • Latest
      J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory