About   Help   FAQ
Lyst Gene Detail
Summary
  • Symbol
    Lyst
  • Name
    lysosomal trafficking regulator
  • Synonyms
    D13Sfk13
  • Feature Type
    protein coding gene
  • IDs
    MGI:107448
    NCBI Gene: 17101
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:13764982-13953388 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 5.28 cM
  • Mapping Data
    44 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4407 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107448
 protein coding gene Chr13:13764896-13953388 (+)
129S1/SvImJ ENSMUSG00200012847
 protein coding gene Chr13:10981283-11188333 (+)
A/J ENSMUSG00195012551
 protein coding gene Chr13:10030989-10249362 (+)
AKR/J ENSMUSG00220027205
 protein coding gene Chr13:10062369-10267457 (+)
BALB/cJ ENSMUSG00180033578
 protein coding gene Chr13:10380077-10598453 (+)
C3H/HeJ ENSMUSG00175029574
 protein coding gene Chr13:10489037-10699802 (+)
C57BL/6NJ ENSMUSG00215021412
 protein coding gene Chr13:10497400-10708178 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018230
 protein coding gene Chr13:9266781-9439007 (+)
CAST/EiJ ENSTCUG00005012648
 protein coding gene Chr13:10628118-10845984 (+)
CBA/J ENSMUSG00210027887
 protein coding gene Chr13:10354613-10565397 (+)
DBA/2J ENSMUSG00185012605
 protein coding gene Chr13:11049343-11260115 (+)
FVB/NJ ENSMUSG00205045185
 protein coding gene Chr13:10304507-10490907 (+)
JF1/MsJ ENSUMUG00000015259
 protein coding gene Chr13:10890832-11095994 (+)
LP/J ENSMUSG00230034572
 protein coding gene Chr13:20458362-20669113 (+)
NOD/ShiLtJ ENSMUSG00190018738
 protein coding gene Chr13:10359681-10570476 (+)
NZO/HlLtJ ENSMUSG00225031829
 protein coding gene Chr13:14224606-14435339 (+)
PWK/PhJ ENSLUMG00010016990
 protein coding gene Chr13:9846563-10057833 (+)
SPRET/EiJ ENSMSPG00010022159
 protein coding gene Chr13:9524505-9718786 (+)
WSB/EiJ ENSIUOG00005020951
 protein coding gene Chr13:9731677-9938768 (+)



Homology
more
  • Human Ortholog
    LYST, lysosomal trafficking regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYST, lysosomal trafficking regulator
  • Synonyms
    CHS, CHS1, Mauve
  • Links
    NCBI Gene ID: 1130
    UniProt: Q99698

  • Chr Location
    1q42.3; chr1:235661031-235883724 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Lyst mouse models; 1 with human LYST associations

Human Disease Mouse Models
      
IDs
 View 9 models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    9 with disease annotations
  • References
    18 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotypes from 24 alleles in 27 genetic backgrounds
    49 phenotypes from multigenic genotypes
    3 images
    208 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice have a phenotype similar to human Chediak-Higashi syndrome patients, exhibiting lysosomal dysfunction with resultant protein storage; diluted coat color; abnormal melanogenesis; immune cell dysfunction resulting in increased susceptibility to bacterial, viral, and parasitic infections and decreased cytotoxic activity against tumor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    1
  • cDNA Data
    64
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019726 Ensembl Gene Model | MGI Sequence Detail 188407 C57BL/6J ±  kb
    transcript ENSMUST00000110559 Ensembl | MGI Sequence Detail 13181 Not Applicable  
    polypeptide ENSMUSP00000106188 Ensembl | MGI Sequence Detail 3787 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 91
      Genomic 22
      cDNA 66
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1543, MGD-MRK-25650, MGD-MRK-35919, MGI:104322
    References
    more
    • Summaries
      All 272
      Developmental Gene Expression 2
      Diseases 18
      Gene Ontology 28
      Phenotypes 208
    • Earliest
      J:2484 Truslove GM, Genetical studies on the skeleton of the mouse. V. 'Interfrontal' and 'parted frontals'. J Genet. 1952;51(1):115-122
    • Latest
      J:364426 Tsao LC, et al., Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd). Nat Commun. 2025 Apr 2;16(1):3167
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory