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H1f3 Gene Detail
Summary
  • Symbol
    H1f3
  • Name
    H1.3 linker histone, cluster member
  • Synonyms
    H1.3, H1D, H1f3, H1s-4, Hist1h1d
  • Feature Type
    protein coding gene
  • IDs
    MGI:107502
    NCBI Gene: 14957
  • Member of
    Hist1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23739206-23739981 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 9.79 cM, cytoband A2-A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107502
 protein coding gene Chr13:23737436-23744860 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020349
 protein coding gene Chr13:20972028-20973125 (+)
A/J MGP_AJ_G0020304
 protein coding gene Chr13:20594572-20595856 (+)
AKR/J MGP_AKRJ_G0020278
 protein coding gene Chr13:20845805-20846808 (+)
BALB/cJ MGP_BALBcJ_G0020294
 protein coding gene Chr13:20584289-20585032 (+)
C3H/HeJ MGP_C3HHeJ_G0020102
 protein coding gene Chr13:20919508-20920198 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0018319
 protein coding gene Chr13:19396893-19397636 (+)
CAST/EiJ MGP_CASTEiJ_G0019621
 protein coding gene Chr13:20609198-20609941 (+)
CBA/J MGP_CBAJ_G0020053
 protein coding gene Chr13:22583978-22585240 (+)
DBA/2J MGP_DBA2J_G0020178
 protein coding gene Chr13:20136859-20137602 (+)
FVB/NJ MGP_FVBNJ_G0020165
 protein coding gene Chr13:19781366-19783121 (+)
LP/J MGP_LPJ_G0020250
 protein coding gene Chr13:21297986-21298729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020194
 protein coding gene Chr13:22895745-22896488 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020769
 protein coding gene Chr13:20698148-20698891 (+)
PWK/PhJ MGP_PWKPhJ_G0019373
 protein coding gene Chr13:20106046-20117144 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019187
 protein coding gene Chr13:19490302-19492020 (+)
WSB/EiJ MGP_WSBEiJ_G0019677
 protein coding gene Chr13:20832423-20833166 (+)



Homology
more
  • Human Ortholog
    H1-3, H1.3 linker histone, cluster member
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H1-3, H1.3 linker histone, cluster member
  • Synonyms
    H1.3, H1D, H1F3, H1s-2, HIST1H1D
  • Links
    NCBI Gene ID: 3007
    neXtProt AC: NX_P16402
    UniProt: P16402

  • Chr Location
    6p22.2; chr6:26234212-26234987 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    22 phenotypes from multigenic genotypes
    15 phenotype references
Homozygotes for targeted null mutations are phenotypically normal. However, Hist1h1c/Hist1h1e/Hist1h1d triple knockout mice die by embryonic day 12.5, and heterozygotes are underrepresented.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    14
  • cDNA Data
    9
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14957 NCBI Gene Model | MGI Sequence Detail 776 C57BL/6J ±  kb
transcript NM_145713 RefSeq | MGI Sequence Detail 776 C57BL/6  
polypeptide P43277 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    Genomic 1
    cDNA 9
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-36072, MGI:6324984
References
more
  • Summaries
    All 57
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:249818 Izzo A, et al., Dynamic changes in H1 subtype composition during epigenetic reprogramming. J Cell Biol. 2017 Aug 9;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory